Seventeen patients with heavily pretreated head and neck squamous cell carcinoma were submitted to a combination of 5-fluorouracil, 500 mg/m2 on days 1-4, and cis-platin, 50 mg/m2 on day 5, repeated every 21 days. Before administration of 5-fluorouracil, N5,N10-methyltetrahydrofolate, 200 mg/m2 i.v., was given. Only 1 partial response and 4 stable disease were observed, and the median survival of the entire group was 5 months. Although all patients had been heavily pretreated and a considerable percentage (6/17, 35.2\%) of these showed resistance to first-line therapy, this combination seems to be ineffective as second-line therapy in head and neck cancer.

Ineffectiveness of 5-fluorouracil and cis-platin as second-line chemotherapy in head and neck cancer / M., Merlano; Conte, Pierfranco; R., Tatarek; P., Scarsi; A., Barbieri; G., Benedetti; R., Rosso. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 70:(1984), pp. 267-269.

Ineffectiveness of 5-fluorouracil and cis-platin as second-line chemotherapy in head and neck cancer.

CONTE, Pierfranco;
1984

Abstract

Seventeen patients with heavily pretreated head and neck squamous cell carcinoma were submitted to a combination of 5-fluorouracil, 500 mg/m2 on days 1-4, and cis-platin, 50 mg/m2 on day 5, repeated every 21 days. Before administration of 5-fluorouracil, N5,N10-methyltetrahydrofolate, 200 mg/m2 i.v., was given. Only 1 partial response and 4 stable disease were observed, and the median survival of the entire group was 5 months. Although all patients had been heavily pretreated and a considerable percentage (6/17, 35.2\%) of these showed resistance to first-line therapy, this combination seems to be ineffective as second-line therapy in head and neck cancer.
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Ineffectiveness of 5-fluorouracil and cis-platin as second-line chemotherapy in head and neck cancer / M., Merlano; Conte, Pierfranco; R., Tatarek; P., Scarsi; A., Barbieri; G., Benedetti; R., Rosso. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 70:(1984), pp. 267-269.
M., Merlano; Conte, Pierfranco; R., Tatarek; P., Scarsi; A., Barbieri; G., Benedetti; R., Rosso
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/738284
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