In this article we have studied the formation of free radical intermediates induced by paraquat, whose toxicity is well known, and by the anti-tumour agent adriamycin in isolated rat hepatocytes comparing the results to those obtained using an iron chelate, such as ADP-iron, a strong inducer of lipid peroxidation. Both paraquat and adriamycin give rise to toxic reactive species of oxygen, our goal being that of inducing an oxidative stress in the model system used.

Ascorbyl radical is detected in rat isolated hepatocytes suspensions undergoing oxidative stress: an early index of oxidative damage in cells / Tomasi, Aldo; E., Albano; A., Bini; Iannone, Anna; V., Vannini. - STAMPA. - 76:(1989), pp. 325-334.

Ascorbyl radical is detected in rat isolated hepatocytes suspensions undergoing oxidative stress: an early index of oxidative damage in cells

TOMASI, Aldo;IANNONE, Anna;
1989

Abstract

In this article we have studied the formation of free radical intermediates induced by paraquat, whose toxicity is well known, and by the anti-tumour agent adriamycin in isolated rat hepatocytes comparing the results to those obtained using an iron chelate, such as ADP-iron, a strong inducer of lipid peroxidation. Both paraquat and adriamycin give rise to toxic reactive species of oxygen, our goal being that of inducing an oxidative stress in the model system used.
1989
76
325
334
Tomasi, Aldo; E., Albano; A., Bini; Iannone, Anna; V., Vannini
Ascorbyl radical is detected in rat isolated hepatocytes suspensions undergoing oxidative stress: an early index of oxidative damage in cells / Tomasi, Aldo; E., Albano; A., Bini; Iannone, Anna; V., Vannini. - STAMPA. - 76:(1989), pp. 325-334.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/737742
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