PURPOSE The International Peripheral T-Cell Lymphoma Project was undertaken to better understand the subtypes of T-cell and natural killer (NK) -cell lymphomas. PATIENTS AND METHODSAngioimmunoblastic T-cell lymphoma (AITL) was diagnosed according to the 2001 WHO criteria by a central review process consisting of panels of expert hematopathologists. Clinical, pathologic, immunophenotyping, treatment, and survival data were correlated. RESULTS: age ≥ 60 years, stages III to IV disease, lactic dehydrogenase (LDH) > normal, extranodal sites (ENSs) > one, and performance status (PS) ≥ 2; the Prognostic Index for Peripheral T-Cell Lymphoma, comprising: age ≥ 60 years, PS ≥ 2, LDH > normal, and bone marrow involvement; and the alternative Prognostic Index for AITL (PIAI), comprising: age > 60 years, PS ≥ 2, ENSs > one, B symptoms, and platelet count < 150 × 10(9)/L. The simplified PIAI had a low-risk group (zero to one factors), with 5-year survival of 44%, and a high-risk group (two to five factors), with 5-year survival of 24% (P = .0065). CONCLUSIONAITL is a rare clinicopathologic entity characterized by an aggressive course and dismal outcome with current therapies.

Clinicopathologic characteristics of angioimmunoblastics T-cell lymphoma (AITL): analysis of 243 cases from the International Peripheral T-cell Lymphoma Project / Federico, Massimo; Rudiger, T.; Bellei, Monica; Nathwani, B. N.; Luminari, Stefano; Coiffier, B.; Harris, N. L.; Jaffe, E.; Pileri, S.; Savane, K. J.; Weisenburger, D. D.; Armitage, J. O.; Mounier, N.; Vose, J. M.. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0732-183X. - ELETTRONICO. - 31:2:(2013), pp. 240-246. [10.1200/JCO.2011.37.3647]

Clinicopathologic characteristics of angioimmunoblastics T-cell lymphoma (AITL): analysis of 243 cases from the International Peripheral T-cell Lymphoma Project.

FEDERICO, Massimo;BELLEI, Monica;LUMINARI, Stefano;
2013-01-01

Abstract

PURPOSE The International Peripheral T-Cell Lymphoma Project was undertaken to better understand the subtypes of T-cell and natural killer (NK) -cell lymphomas. PATIENTS AND METHODSAngioimmunoblastic T-cell lymphoma (AITL) was diagnosed according to the 2001 WHO criteria by a central review process consisting of panels of expert hematopathologists. Clinical, pathologic, immunophenotyping, treatment, and survival data were correlated. RESULTS: age ≥ 60 years, stages III to IV disease, lactic dehydrogenase (LDH) > normal, extranodal sites (ENSs) > one, and performance status (PS) ≥ 2; the Prognostic Index for Peripheral T-Cell Lymphoma, comprising: age ≥ 60 years, PS ≥ 2, LDH > normal, and bone marrow involvement; and the alternative Prognostic Index for AITL (PIAI), comprising: age > 60 years, PS ≥ 2, ENSs > one, B symptoms, and platelet count < 150 × 10(9)/L. The simplified PIAI had a low-risk group (zero to one factors), with 5-year survival of 44%, and a high-risk group (two to five factors), with 5-year survival of 24% (P = .0065). CONCLUSIONAITL is a rare clinicopathologic entity characterized by an aggressive course and dismal outcome with current therapies.
31:2
240
246
Clinicopathologic characteristics of angioimmunoblastics T-cell lymphoma (AITL): analysis of 243 cases from the International Peripheral T-cell Lymphoma Project / Federico, Massimo; Rudiger, T.; Bellei, Monica; Nathwani, B. N.; Luminari, Stefano; Coiffier, B.; Harris, N. L.; Jaffe, E.; Pileri, S.; Savane, K. J.; Weisenburger, D. D.; Armitage, J. O.; Mounier, N.; Vose, J. M.. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0732-183X. - ELETTRONICO. - 31:2:(2013), pp. 240-246. [10.1200/JCO.2011.37.3647]
Federico, Massimo; Rudiger, T.; Bellei, Monica; Nathwani, B. N.; Luminari, Stefano; Coiffier, B.; Harris, N. L.; Jaffe, E.; Pileri, S.; Savane, K. J.; Weisenburger, D. D.; Armitage, J. O.; Mounier, N.; Vose, J. M.
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