Structural brain changes have been described in both mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, less is known about whether structural changes are detectable earlier, in the asymptomatic phase. Using voxel-based morphometry (VBM) and shape analyses of magnetic resonance imaging (MRI) data, we investigated structural brain differences between groups of healthy subjects, stratified by subsequent diagnoses of MCI or AD during a 10-year follow-up. Images taken at baseline, at least 4 years before any cognitive symptoms, showed that subjects with future cognitive impairment (preclinical AD and MCI) had reduced brain volume in medial temporal lobes, posterior cingulate/precuneus, and orbitofrontal cortex, compared with matched subjects who remained cognitively healthy for 10 years (HC). For only those subjects later diagnosed as AD, significantly greater atrophy at baseline was detected in the right medial temporal lobe, which was also confirmed by shape analysis of the right hippocampus in these subjects. Our results demonstrate that structural brain changes occur years before clinical cognitive decline in AD and are localized to regions affected by AD neuropathology.

Structural MRI changes detectable up to ten years before clinical Alzheimer's disease / Tondelli, Manuela; G. K., Wilcock; Nichelli, Paolo Frigio; C. A., De Jager; M., Jenkinson; Zamboni, Giovanna. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - ELETTRONICO. - 33:(2012), pp. 825-836. [10.1016/j.neurobiolaging.2011.05.018]

Structural MRI changes detectable up to ten years before clinical Alzheimer's disease

TONDELLI, Manuela;NICHELLI, Paolo Frigio;ZAMBONI, Giovanna
2012

Abstract

Structural brain changes have been described in both mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, less is known about whether structural changes are detectable earlier, in the asymptomatic phase. Using voxel-based morphometry (VBM) and shape analyses of magnetic resonance imaging (MRI) data, we investigated structural brain differences between groups of healthy subjects, stratified by subsequent diagnoses of MCI or AD during a 10-year follow-up. Images taken at baseline, at least 4 years before any cognitive symptoms, showed that subjects with future cognitive impairment (preclinical AD and MCI) had reduced brain volume in medial temporal lobes, posterior cingulate/precuneus, and orbitofrontal cortex, compared with matched subjects who remained cognitively healthy for 10 years (HC). For only those subjects later diagnosed as AD, significantly greater atrophy at baseline was detected in the right medial temporal lobe, which was also confirmed by shape analysis of the right hippocampus in these subjects. Our results demonstrate that structural brain changes occur years before clinical cognitive decline in AD and are localized to regions affected by AD neuropathology.
2012
33
825
836
Structural MRI changes detectable up to ten years before clinical Alzheimer's disease / Tondelli, Manuela; G. K., Wilcock; Nichelli, Paolo Frigio; C. A., De Jager; M., Jenkinson; Zamboni, Giovanna. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - ELETTRONICO. - 33:(2012), pp. 825-836. [10.1016/j.neurobiolaging.2011.05.018]
Tondelli, Manuela; G. K., Wilcock; Nichelli, Paolo Frigio; C. A., De Jager; M., Jenkinson; Zamboni, Giovanna
File in questo prodotto:
File Dimensione Formato  
Tondelli et al.pdf

Accesso riservato

Descrizione: Articolo principale
Tipologia: Versione pubblicata dall'editore
Dimensione 1.72 MB
Formato Adobe PDF
1.72 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/736875
Citazioni
  • ???jsp.display-item.citation.pmc??? 91
  • Scopus 183
  • ???jsp.display-item.citation.isi??? 175
social impact