A new protocol, based on a modified replication method, is proposed to obtain bioactive glass scaffolds. The main feature of these samples, named ‘‘shell scaffolds’’, is their external surface that, like a compact and porous shell, provides both high permeability to fluids and mechanical support. In this work, two different scaffolds were prepared using the following slurry components: 59 % water, 29 % 45S5 BioglassÒ and 12 % polyvinylic binder and 51 % water, 34 % 45S5 BioglassÒ, 10 % polyvinylic binder and 5 % polyethylene. All the proposed samples were charac- terized by a widespread microporosity and an intercon- nected macroporosity, with a total porosity of 80 % vol. After immersion in a simulated body fluid (SBF), the scaffolds showed strong ability to develop hydroxyapatite, enhanced by the high specific surface of the porous systems. Moreover preliminary biological evaluations suggested a promising role of the shell scaffolds for applications in bone tissue regeneration. As regards the mechanical behaviour, the shell scaffolds could be easily handled without damages, due to their resistant external surface. More specifically, they possessed suitable mechanical properties for bone regeneration, as proved by compression tests performed before and after immersion in SBF.

Processing and characterization of innovative scaffolds for bone tissue engineering / Bellucci, Devis; F., Chiellini; G., Ciardelli; M., Gazzarri; P., Gentile; Sola, Antonella; Cannillo, Valeria. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - STAMPA. - 23:6(2012), pp. 1397-1409. [10.1007/s10856-012-4622-6]

Processing and characterization of innovative scaffolds for bone tissue engineering

BELLUCCI, Devis;SOLA, Antonella;CANNILLO, Valeria
2012

Abstract

A new protocol, based on a modified replication method, is proposed to obtain bioactive glass scaffolds. The main feature of these samples, named ‘‘shell scaffolds’’, is their external surface that, like a compact and porous shell, provides both high permeability to fluids and mechanical support. In this work, two different scaffolds were prepared using the following slurry components: 59 % water, 29 % 45S5 BioglassÒ and 12 % polyvinylic binder and 51 % water, 34 % 45S5 BioglassÒ, 10 % polyvinylic binder and 5 % polyethylene. All the proposed samples were charac- terized by a widespread microporosity and an intercon- nected macroporosity, with a total porosity of 80 % vol. After immersion in a simulated body fluid (SBF), the scaffolds showed strong ability to develop hydroxyapatite, enhanced by the high specific surface of the porous systems. Moreover preliminary biological evaluations suggested a promising role of the shell scaffolds for applications in bone tissue regeneration. As regards the mechanical behaviour, the shell scaffolds could be easily handled without damages, due to their resistant external surface. More specifically, they possessed suitable mechanical properties for bone regeneration, as proved by compression tests performed before and after immersion in SBF.
2012
23
6
1397
1409
Processing and characterization of innovative scaffolds for bone tissue engineering / Bellucci, Devis; F., Chiellini; G., Ciardelli; M., Gazzarri; P., Gentile; Sola, Antonella; Cannillo, Valeria. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - STAMPA. - 23:6(2012), pp. 1397-1409. [10.1007/s10856-012-4622-6]
Bellucci, Devis; F., Chiellini; G., Ciardelli; M., Gazzarri; P., Gentile; Sola, Antonella; Cannillo, Valeria
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/736856
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 33
social impact