The structure of a number of 2-exo-methylene substituted quinazolines and benzodiazepines, respectively, 1, 3a,b, I (X = -CN, -COOEt) and their 2-cyanoimino substituted analogues 2, 3c,d (X = -CN, -SO2C6H4-Me(p) was completely assigned by the whole arsenal of 1D and 2D NMR spectroscopic methods, The E/Z isomerism at the exo-cyclic double bond was determined by both NMR spectroscopy and confirmed by ab initio quantum chemical calculations; the Z isomer is the preferred one, its amount proved dependent on steric hindrance. Due to the push-pull effect in this part of the molecules the restricted rotation about the partial C-2,C-11 and C-2,N-11 double bonds, could also be studied and the barrier to rotation measured by dynamic NMR spectroscopy. The free energies of activation of this dynamic process proved very similar along the compounds studied but being dependent on the polarity of the solvent. Quantum chemical calculations at the ab initio level were employed to prove the stereochemistry at the exo-cyclic partial double bonds of 1-4, to calculate thr barriers to rotation but also to discuss in detail both the ground and the transition state of the latter dynamic process in order to better understand electronic, inter- and intramolecular effects on the barrier to rotation which could be determined experimentally. in the cyanoimino substituted compounds 2, 3c,d, the MO ab initio calculations evidence the isomer interconversion to be better described by the internal rotation process than by the lateral shift mechanism. (C) 2000 Elsevier Science Publishers B.V. All rights reserved.
|Anno di pubblicazione:||2000|
|Titolo:||Exocyclic push-pull conjugated compounds. Part 3. An experimental NMR and theoretical MO ab initio study of the structure, the electronic properties and barriers to rotation about the exocyclic partial double bond in 2-exo-methylene- and 2-cyanoimino-quin|
|Autore/i:||Benassi R; Bertarini C; Hilfert L; Kempter G; Kleinpeter E; Spindler J; Taddei F; Thomas S|
|Codice identificativo ISI:||ISI:000085905500030|
|Codice identificativo Scopus:||2-s2.0-0034646333|
|Tipologia||Articolo su rivista|
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