Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humansis limited. Six hundred four fertilemen(199 from Greenland, 197 from Poland and 208 from Ukraine) wereenrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrentDNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyltransferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptorand Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptoticmarkers or reproductive hormones emerged.Weobserved a slight increase in SHBG and TUNEL-positivitywith increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposureinterferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found.
Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances – A study of spouses of pregnant women in three geographical regions / Olmer Specht I, 9. 1.; Hougaard, Ks; Spanò, M; Bizzaro, D; Manicardi, Gian Carlo; Lindh, Cg; Toft, G; Jönsson, Bag; Giwercman, A; Bonde, Jp. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - STAMPA. - 33:4(2012), pp. 577-583. [10.1016/j.reprotox.2012.02.008]
Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances – A study of spouses of pregnant women in three geographical regions.
MANICARDI, Gian Carlo;
2012
Abstract
Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humansis limited. Six hundred four fertilemen(199 from Greenland, 197 from Poland and 208 from Ukraine) wereenrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrentDNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyltransferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptorand Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptoticmarkers or reproductive hormones emerged.Weobserved a slight increase in SHBG and TUNEL-positivitywith increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposureinterferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found.
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