RNA binding proteins belonging to the TIS11/TTP gene family regulate the stability of multiple targets. Their inactivation or deregulated expression has recently been related to cancer, and it has been suggested that they are capable of displaying tumor suppressor activities. Here we describe three new targets of ZFP36 (PIM-1, PIM-3 and XIAP) and show by different approaches that its ectopic expression is capable of impairing glioblastoma cell lines viability and invasiveness by interfering with different transduction pathways. Moreover, we provide evidence that compounds capable of inducing the expression of TIS11/TTP genes determine a comparable biological effect on the same cell contexts.

ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways / Selmi, Tommaso; Martello, Andrea; Vignudelli, Tatiana; Ferrari, Erika; Grande, Alexis; Gemelli, Claudia; Salomoni, P; Ferrari, Sergio; ZANOCCO MARANI, Tommaso. - In: CELL CYCLE. - ISSN 1538-4101. - STAMPA. - 11:10(2012), pp. 1977-1987. [10.4161/cc.20309]

ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways.

SELMI, TOMMASO;MARTELLO, Andrea;VIGNUDELLI, Tatiana;FERRARI, Erika;GRANDE, Alexis;GEMELLI, Claudia;FERRARI, Sergio;ZANOCCO MARANI, Tommaso
2012

Abstract

RNA binding proteins belonging to the TIS11/TTP gene family regulate the stability of multiple targets. Their inactivation or deregulated expression has recently been related to cancer, and it has been suggested that they are capable of displaying tumor suppressor activities. Here we describe three new targets of ZFP36 (PIM-1, PIM-3 and XIAP) and show by different approaches that its ectopic expression is capable of impairing glioblastoma cell lines viability and invasiveness by interfering with different transduction pathways. Moreover, we provide evidence that compounds capable of inducing the expression of TIS11/TTP genes determine a comparable biological effect on the same cell contexts.
2012
11
10
1977
1987
ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways / Selmi, Tommaso; Martello, Andrea; Vignudelli, Tatiana; Ferrari, Erika; Grande, Alexis; Gemelli, Claudia; Salomoni, P; Ferrari, Sergio; ZANOCCO MARANI, Tommaso. - In: CELL CYCLE. - ISSN 1538-4101. - STAMPA. - 11:10(2012), pp. 1977-1987. [10.4161/cc.20309]
Selmi, Tommaso; Martello, Andrea; Vignudelli, Tatiana; Ferrari, Erika; Grande, Alexis; Gemelli, Claudia; Salomoni, P; Ferrari, Sergio; ZANOCCO MARANI,...espandi
File in questo prodotto:
File Dimensione Formato  
cc.20309.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 3.34 MB
Formato Adobe PDF
3.34 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/727247
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 28
social impact