Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (PNALT). A total of 121 PNALT patients did not receive any antiviral treatment but underwent periodic clinical monitoring, including repeat biopsies, for a median of 120 months. IL6-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C polymorphisms were related to histologic fibrosis progression. Among patients whose grading and staging scores increased at the end of the follow-up ≥2 Ishak points (N = 60 and N = 26, respectively), IL-6 -174G>C genotype frequencies were GG 37/66, GC 21/45, CC 2/10 (p = 0.041) and GG 18/66, GC 8/45, CC 0/10 (p = 0.040), respectively. The following frequencies were observed for the 572G>C polymorphism: GG 50/105, GC 10/16, CC 0/0, and GG 19/105, GC 7/16, CC 0/0, respectively. Grading progression was independently associated with carriage of the G allele in -174G>C polymorphism (oddd ratio = 5.07%, 95% confidence interval = 0.959–26.8, p = 0.023). Staging progression was independently associated with carriage of the C allele in -572G>C polymorphism (odd ratio = 4.60%, 95% confidence interval 1.42–14.8, p = 0.012). IL-6 polymorphisms influence histologic progression of HCV in patients with PNALT.

Genetic polymorphisms of interleukin-6 modulates fibrosis progression in mild chronic hepatitis C / Falleti, E.; Fabris, C.; Vandelli, Carmen; Colletta, C.; Cussig, A.; Smirne, C.; Fontanini, E.; Cmet, S.; Minisini, R.; Bitetto, D.; Toniutto, P.; Pirisi, M.. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - ELETTRONICO. - 71(2010), pp. 999-1004. [10.1016/j.humimm.2010.06.006]

Genetic polymorphisms of interleukin-6 modulates fibrosis progression in mild chronic hepatitis C.

VANDELLI, Carmen;
2010

Abstract

Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (PNALT). A total of 121 PNALT patients did not receive any antiviral treatment but underwent periodic clinical monitoring, including repeat biopsies, for a median of 120 months. IL6-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C polymorphisms were related to histologic fibrosis progression. Among patients whose grading and staging scores increased at the end of the follow-up ≥2 Ishak points (N = 60 and N = 26, respectively), IL-6 -174G>C genotype frequencies were GG 37/66, GC 21/45, CC 2/10 (p = 0.041) and GG 18/66, GC 8/45, CC 0/10 (p = 0.040), respectively. The following frequencies were observed for the 572G>C polymorphism: GG 50/105, GC 10/16, CC 0/0, and GG 19/105, GC 7/16, CC 0/0, respectively. Grading progression was independently associated with carriage of the G allele in -174G>C polymorphism (oddd ratio = 5.07%, 95% confidence interval = 0.959–26.8, p = 0.023). Staging progression was independently associated with carriage of the C allele in -572G>C polymorphism (odd ratio = 4.60%, 95% confidence interval 1.42–14.8, p = 0.012). IL-6 polymorphisms influence histologic progression of HCV in patients with PNALT.
71
999
1004
Genetic polymorphisms of interleukin-6 modulates fibrosis progression in mild chronic hepatitis C / Falleti, E.; Fabris, C.; Vandelli, Carmen; Colletta, C.; Cussig, A.; Smirne, C.; Fontanini, E.; Cmet, S.; Minisini, R.; Bitetto, D.; Toniutto, P.; Pirisi, M.. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - ELETTRONICO. - 71(2010), pp. 999-1004. [10.1016/j.humimm.2010.06.006]
Falleti, E.; Fabris, C.; Vandelli, Carmen; Colletta, C.; Cussig, A.; Smirne, C.; Fontanini, E.; Cmet, S.; Minisini, R.; Bitetto, D.; Toniutto, P.; Pirisi, M.
File in questo prodotto:
File Dimensione Formato  
genetic polymorphisms human immunology 2010.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 435.3 kB
Formato Adobe PDF
435.3 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/722054
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 29
social impact