The current TNM staging system for non-small cell lung cancer subdivides stage IA and IB according to a tumor size threshold of 3 cm. Some authors have suggested that tumor size behaves as a continuous, but the optimal diameter thresholds to be adopted remain debated.We conducted a retrospective study on 548 patients who underwent a complete surgical resection at our institute for stage IA and IB non-small cell lung cancer according to the current TNM staging system. Univariate and multiaviate analysis of overall and disease-specific survival were performed.Stage IA had an overall 5 years survival of 67\% and a 5 years disease-specific survival of 85\%. Stage IB had an overall 5 years of 49\% and 5 years disease-specific survival of 53\%. Tumors <2 cm had a significantly better survival than tumors > or =2 cm (overall survival: p=0.007; disease-specific survival: p=0.026), as well as tumors ranging from 2 to 5 cm in comparison with larger ones (overall survival: p=0.031; disease-specific survival: p=0.013). No significant difference was found between groups ranging from 2 to 5 cm. Tumors of 2-5 cm had 57\% higher probability of death in comparison with tumors <2 cm and tumors >5 cm had a probability of death 60\% higher than tumor of 2-5 cm. Age and tumor size (two thresholds diameter classification) resulted independent variables at multivariate analysis.the definition of T factor in the staging system of non-small cell lung cancer should consider two cutoffs according to tumor size. Two and 5 cm represent appropriate thresholds diameters that define subgroups with significant different prognosis.
|Data di pubblicazione:||2006|
|Titolo:||The prognostic impact of tumor size in resected stage I non-small cell lung cancer: evidence for a two thresholds tumor diameters classification.|
|Autore/i:||C. Casali; E. Storelli; U. Morandi|
|Digital Object Identifier (DOI):||10.1016/j.lungcan.2006.08.003|
|Codice identificativo ISI:||WOS:000241806900008|
|Codice identificativo Scopus:||2-s2.0-33751114722|
|Citazione:||The prognostic impact of tumor size in resected stage I non-small cell lung cancer: evidence for a two thresholds tumor diameters classification. / C. Casali; E. Storelli; U. Morandi. - In: LUNG CANCER. - ISSN 0169-5002. - STAMPA. - 54(2006), pp. 185-191.|
|Tipologia||Articolo su rivista|
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