The synthesis and enantioseparation of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives are reported herein. A HPLC stopped-flow procedure was applied to the determination of rate constants and free energy barriers of enantiomerization of the compounds synthesized in the presence of achiral stationary phase. The individual enantiomers of the studied compounds were isolated in parallel by preparative HPLC on a Chiraspher NT column. Rate constants and free energy barriers of enantiomerization were determined in the mobile phase. The results were used to determine the influence of the chiral stationary phase on the enantiomerization process.

The synthesis and enantioseparation of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives are reported herein. A HPLC stopped-flow procedure was applied to the determination of rate constants and free energy barriers of enantiomerization of the compounds synthesized in the presence of achiral stationary phase. The individual enantiomers of the studied compounds were isolated in parallel by preparative HPLC on a Chiraspher NT column. Rate constants and free energy barriers of enantiomerization were determined in the mobile phase. The results were used to determine the influence of the chiral stationary phase on the enantiomerization process. © 2006 Elsevier Ltd. All rights reserved.

Energy barrier determination of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds by enantioselective stopped-flow HPLC / Cannazza, Giuseppe; Braghiroli, Daniela; Iuliani, Piera; Parenti, Carlo. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 17:22(2006), pp. 3158-3162. [10.1016/j.tetasy.2006.11.035]

Energy barrier determination of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds by enantioselective stopped-flow HPLC

CANNAZZA, Giuseppe;BRAGHIROLI, Daniela;PARENTI, Carlo
2006

Abstract

The synthesis and enantioseparation of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives are reported herein. A HPLC stopped-flow procedure was applied to the determination of rate constants and free energy barriers of enantiomerization of the compounds synthesized in the presence of achiral stationary phase. The individual enantiomers of the studied compounds were isolated in parallel by preparative HPLC on a Chiraspher NT column. Rate constants and free energy barriers of enantiomerization were determined in the mobile phase. The results were used to determine the influence of the chiral stationary phase on the enantiomerization process.
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Energy barrier determination of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds by enantioselective stopped-flow HPLC / Cannazza, Giuseppe; Braghiroli, Daniela; Iuliani, Piera; Parenti, Carlo. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 17:22(2006), pp. 3158-3162. [10.1016/j.tetasy.2006.11.035]
Cannazza, Giuseppe; Braghiroli, Daniela; Iuliani, Piera; Parenti, Carlo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/716045
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