Past, present and future of myoblasttransplantation in the treatment ofDuchenne muscular dystrophy

DMD is a genetic X-linked recessive disease that affectsapproximately one in 3500 male births. Boys with DMD have progressiveand predictable muscle destruction because of the absence ofDys, a protein present under the muscle fiber membrane. Dys deficiencyinduces contraction-related membrane damages, activation of inflammatory-necrosis-fibrosis up to the cardiac-diaphragmatic failure anddeath. This review supports the therapeutic role of MT associated withimmunosuppression in DMD patients, describing the history and therationale of such approach. The authors underline the importance toevaluate a protocol of myoblast intradermal multi-injection to apply inyoung DMD patients.