In the ovary, Anti-Müllerian hormone (AMH) is produced by the granulosa cells of early developing follicles and inhibits the transition from the primordial to the primary follicular stage. AMH levels can be measured in serum and have been shown to be proportional to the number of small antral follicles. In women serum AMH levels decrease with age and are undetectable in the post-menopausal period. In patients with premature ovarian failure AMH is undetectable or greatly reduced depending of the number of antral follicles in the ovaries. In contrast, AMH levels have been shown to be increased in women with polycystic ovary syndrome (PCOS). AMH levels appear to represent the quantity of the ovarian follicle pool and may become a useful marker of ovarian reserve. AMH measurement could also be useful in the prediction of the extremes of ovarian response to gonadotrophin stimulation for in vitro fertilization, namely poor- and hyper-response. Although AMH has the potential to increase our understanding of ovarian pathophysiology, and to guide clinical management in a broad range of conditions, a number of important questions relating to both the basic physiology of AMH and its clinical implications need to be answered.

Anti-Mullerian hormone (AMH): what do we still need to know? / Marca, A. L.; F. J., Broekmans; Volpe, Annibale; B. C., Fauser; N. S., Macklon; E. S., H.. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - STAMPA. - 24:9(2009), pp. 2264-2275. [10.1093/humrep/dep210]

Anti-Mullerian hormone (AMH): what do we still need to know?

A. L. Marca;VOLPE, Annibale;
2009-01-01

Abstract

In the ovary, Anti-Müllerian hormone (AMH) is produced by the granulosa cells of early developing follicles and inhibits the transition from the primordial to the primary follicular stage. AMH levels can be measured in serum and have been shown to be proportional to the number of small antral follicles. In women serum AMH levels decrease with age and are undetectable in the post-menopausal period. In patients with premature ovarian failure AMH is undetectable or greatly reduced depending of the number of antral follicles in the ovaries. In contrast, AMH levels have been shown to be increased in women with polycystic ovary syndrome (PCOS). AMH levels appear to represent the quantity of the ovarian follicle pool and may become a useful marker of ovarian reserve. AMH measurement could also be useful in the prediction of the extremes of ovarian response to gonadotrophin stimulation for in vitro fertilization, namely poor- and hyper-response. Although AMH has the potential to increase our understanding of ovarian pathophysiology, and to guide clinical management in a broad range of conditions, a number of important questions relating to both the basic physiology of AMH and its clinical implications need to be answered.
24
9
2264
2275
Anti-Mullerian hormone (AMH): what do we still need to know? / Marca, A. L.; F. J., Broekmans; Volpe, Annibale; B. C., Fauser; N. S., Macklon; E. S., H.. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - STAMPA. - 24:9(2009), pp. 2264-2275. [10.1093/humrep/dep210]
Marca, A. L.; F. J., Broekmans; Volpe, Annibale; B. C., Fauser; N. S., Macklon; E. S., H.
File in questo prodotto:
File Dimensione Formato  
la marca 3.pdf

non disponibili

Tipologia: Versione dell'autore revisionata e accettata per la pubblicazione
Dimensione 259.74 kB
Formato Adobe PDF
259.74 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/712400
Citazioni
  • ???jsp.display-item.citation.pmc??? 89
  • Scopus 274
  • ???jsp.display-item.citation.isi??? 231
social impact