The aim of this study was to assess the influence of chronic therapy with phosphodiesterase type-5 inhibitor on penile haemodynamics at colour Doppler ultrasound. Thirty patients affected by erectile dysfunction (ED) of different aetiology tested with the International Index of Erectile Function (IIEF-5) were evaluated with penile colour Doppler ultrasound during basic and dynamic phases (10 microg PGE1) before and after chronic self-administration of sildenafil citrate (dosage: 100 mg as required, two to three times a week) for a period of 5-20 months (mean: 12.3). Treatment was interrupted 14-21 days before the second ultrasound evaluation. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) were recorded by means of colour Doppler; cut off values were 25 and 5 cm s(-1) respectively. Data were compared by nonparametric tests. Twenty-two of the 30 patients showed normal pre-treatment PSV, while eight of 30 had an insufficient arterial flow. Mean pre-treatment EDV was 4.7 +/- 0.5. After chronic therapy with sildenafil, a global improvement of 10.5% on PSV was seen (P < 0.001), without any statistical difference between patients with normal pre-treatment peak and those with a borderline one. No statistically significant changes were found for EDV (P = 0.98). It is concluded that chronic therapy with phosphodiesterase-5 inhibitor results in a significant improvement in PSV values, probably due to a penile chronic vasoactive enhancement.

Changes in peak systolic velocity induced by chronic therapy with phosphodiesterase type-5 inhibitor / M. C., Sighinolfi; A., Mofferdin; DE STEFANI, Stefano; A., Celia; MICALI, Salvatore; A. F., Cicero; BIANCHI, Giampaolo. - In: ANDROLOGIA. - ISSN 0303-4569. - ELETTRONICO. - 38:3(2006), pp. 84-86. [10.1111/j.1439-0272.2006.00719.x]

Changes in peak systolic velocity induced by chronic therapy with phosphodiesterase type-5 inhibitor

DE STEFANI, Stefano;MICALI, Salvatore;BIANCHI, Giampaolo
2006

Abstract

The aim of this study was to assess the influence of chronic therapy with phosphodiesterase type-5 inhibitor on penile haemodynamics at colour Doppler ultrasound. Thirty patients affected by erectile dysfunction (ED) of different aetiology tested with the International Index of Erectile Function (IIEF-5) were evaluated with penile colour Doppler ultrasound during basic and dynamic phases (10 microg PGE1) before and after chronic self-administration of sildenafil citrate (dosage: 100 mg as required, two to three times a week) for a period of 5-20 months (mean: 12.3). Treatment was interrupted 14-21 days before the second ultrasound evaluation. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) were recorded by means of colour Doppler; cut off values were 25 and 5 cm s(-1) respectively. Data were compared by nonparametric tests. Twenty-two of the 30 patients showed normal pre-treatment PSV, while eight of 30 had an insufficient arterial flow. Mean pre-treatment EDV was 4.7 +/- 0.5. After chronic therapy with sildenafil, a global improvement of 10.5% on PSV was seen (P < 0.001), without any statistical difference between patients with normal pre-treatment peak and those with a borderline one. No statistically significant changes were found for EDV (P = 0.98). It is concluded that chronic therapy with phosphodiesterase-5 inhibitor results in a significant improvement in PSV values, probably due to a penile chronic vasoactive enhancement.
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Changes in peak systolic velocity induced by chronic therapy with phosphodiesterase type-5 inhibitor / M. C., Sighinolfi; A., Mofferdin; DE STEFANI, Stefano; A., Celia; MICALI, Salvatore; A. F., Cicero; BIANCHI, Giampaolo. - In: ANDROLOGIA. - ISSN 0303-4569. - ELETTRONICO. - 38:3(2006), pp. 84-86. [10.1111/j.1439-0272.2006.00719.x]
M. C., Sighinolfi; A., Mofferdin; DE STEFANI, Stefano; A., Celia; Micali, Salvatore; A. F., Cicero; Bianchi, Giampaolo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/709609
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