Neuroimaging data suggest a link between the spontaneous production of thoughts during wakeful rest and slow fluctuations of activity in the default mode network (DMN), a set of brain regions with high basal metabolism and a major neural hub in the ventral posteromedial cortex (vPMC). Meta-awareness and regulation of mind-wandering are core cognitive components of most contemplative practices and to study their impact on DMN activity we collected functional MRI (fMRI) data from a cohort of experienced Zen meditators and meditation-naive controls engaging in a basic attention-to-breathing protocol. We observed a significant group difference in the skewness of the fMRI blood-oxygen level dependent (BOLD) signal from the vPMC, suggesting that the relative incidence of states of elevated vPMC activity was lower in meditators; furthermore, the same parameter was significantly correlated with performance on a rapid visual information processing (RVIP) test for sustained attentionconducted outside the scanner. Finally, a functional connectivity (fc) analysis with the vPMC seed revealed a significant association of RVIP performance and the degree of temporal correlation between vPMC and the right temporo-parietal junction (TPJ),a region strongly implicated in stimulus-triggered reorienting of attention. Taken together, these findings suggest that the vPMC BOLD signal skewness and the temporal relationship of vPMC and TPJ activities reflect the dynamic tension between mind-wandering, meta-awareness, and directed attention, and may represent a use-ful endophenotype for studying individual differences in attentional abilities and the impairment of the latter in specific clinical conditions.
Dynamical properties of BOLD activity from the ventral posteromedial cortex associated with meditation and attentional skills / Pagnoni, Giuseppe. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - STAMPA. - 32(15)(2012), pp. 5242-5249.
|Data di pubblicazione:||2012|
|Titolo:||Dynamical properties of BOLD activity from the ventral posteromedial cortex associated with meditation and attentional skills|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1523/JNEUROSCI.4135-11.2012|
|Codice identificativo ISI:||WOS:000302793500023|
|Codice identificativo Scopus:||2-s2.0-84859552768|
|Codice identificativo Pubmed:||22496570|
|Citazione:||Dynamical properties of BOLD activity from the ventral posteromedial cortex associated with meditation and attentional skills / Pagnoni, Giuseppe. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - STAMPA. - 32(15)(2012), pp. 5242-5249.|
|Tipologia||Articolo su rivista|
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