Benzodiazepine-like compounds are present in trace amounts in the blood of normal subjects and increase in liver cirrhotic patients with or without encephalopathy. Their increased presence may, however, represent an occasional precipitating factor of hepatic encephalopathy. The source of these compounds is still unknown, but they are constituents of our diet since benzodiazepine receptor ligands have been described in plants, vegetablesand in animals. They may also be synthesized, at least in part, by intestinal bacterial flora. In this article we report that the level of these compounds in the blood decreased by 40%after therapy with rifaximin, which reduces the aerobic and anaerobic intestinal bacterial flora. This observation indicates that intestinal bacterial flora is involved in the production of these compounds and that repeated short-term medications with this non-absorbableantibiotic may be useful in reducing the levels of benzodiazepine-like compounds in patients with liver cirrhosis.

ANTIBACTERIAL ACTIVITY OF RIFAXIMIN REDUCES THE LEVELS OFBENZODIAZEPINE-LIKE COMPOUNDS IN PATIENTS WITH LIVERCIRRHOSIS / Zeneroli, Maria Luisa; I., Venturini; S., Stefanelli; Farina, Franco; R., Cosenza; L., Miglioli; E., Minelli; R., Amedei; A., Ferrieri; Avallone, Rossella; Baraldi, Mario. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 35:(1997), pp. 557-560.

ANTIBACTERIAL ACTIVITY OF RIFAXIMIN REDUCES THE LEVELS OFBENZODIAZEPINE-LIKE COMPOUNDS IN PATIENTS WITH LIVERCIRRHOSIS

ZENEROLI, Maria Luisa;FARINA, Franco;AVALLONE, Rossella;BARALDI, Mario
1997

Abstract

Benzodiazepine-like compounds are present in trace amounts in the blood of normal subjects and increase in liver cirrhotic patients with or without encephalopathy. Their increased presence may, however, represent an occasional precipitating factor of hepatic encephalopathy. The source of these compounds is still unknown, but they are constituents of our diet since benzodiazepine receptor ligands have been described in plants, vegetablesand in animals. They may also be synthesized, at least in part, by intestinal bacterial flora. In this article we report that the level of these compounds in the blood decreased by 40%after therapy with rifaximin, which reduces the aerobic and anaerobic intestinal bacterial flora. This observation indicates that intestinal bacterial flora is involved in the production of these compounds and that repeated short-term medications with this non-absorbableantibiotic may be useful in reducing the levels of benzodiazepine-like compounds in patients with liver cirrhosis.
35
557
560
ANTIBACTERIAL ACTIVITY OF RIFAXIMIN REDUCES THE LEVELS OFBENZODIAZEPINE-LIKE COMPOUNDS IN PATIENTS WITH LIVERCIRRHOSIS / Zeneroli, Maria Luisa; I., Venturini; S., Stefanelli; Farina, Franco; R., Cosenza; L., Miglioli; E., Minelli; R., Amedei; A., Ferrieri; Avallone, Rossella; Baraldi, Mario. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 35:(1997), pp. 557-560.
Zeneroli, Maria Luisa; I., Venturini; S., Stefanelli; Farina, Franco; R., Cosenza; L., Miglioli; E., Minelli; R., Amedei; A., Ferrieri; Avallone, Rossella; Baraldi, Mario
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/708913
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