Eosinophilic fasciitis (EF) is a rare disease characterized by symmetrical thickness and hardening of the skin, especially localized to forearms and thorax, with eosinophilia. Corticosteroids represent the first-line therapy, even if some patients are scarcely responsive and/or may develop important side effects due to long-term treatment. Here, we describe three cases of EF, two of them refractory to previous steroid therapy, successfully treated with D-penicillamine. The present clinical observations together with the updated review of the literature suggest usefulness of D-penicillamine in EF patients, as well as its potential steroid-sparing value.

D-penicillamine in the treatment of eosinophilic fasciitis: case reports and review of the literature / C. U., Manzini; Sebastiani, Marco; D., Giuggioli; Manfredi, Andreina Teresa; Colaci, Michele; A. M., Cesinaro; Ferri, Clodoveo. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 31(2012), pp. 183-187.

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