EnglishOBJECTIVE:No data are available about circulating levels of the CXCL11 chemokine in hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC) patients with or without autoimmune thyroiditis (AT). The aim of the present study, therefore, was to evaluate serum CXCL11 levels in these patients.DESIGN:Serum CXCL11 (and for comparison, CXCL10) was measured in 45 patients with MC, 45 patients with MC and AT (MC + AT), 45 sex- and age-matched controls without AT (control 1), 45 sex- and age-matched patients with AT without cryoglobulinemia (control 2), and in 45 sex- and age-matched patients with hepatitis C chronic infection without MC (HCV+).RESULTS:Serum CXCL11 and CXCL10 levels were significantly higher in control 2 than in control 1 (p < 0.01). MC patients had CXCL11 and CXCL10 significantly higher than control 1 (p < 0.01). MC + AT patients had CXCL11 and CXCL10 higher than control 2 (p < 0.01) and MC patients (p = 0.02). Serum CXCL11 levels were not associated with any of the clinical features of cryoglobulinemia in patients with MC and MC + AT, which was the same for CXCL10. CXCL10 and CXCL11 in HCV+ patients were significantly higher than in controls 1 and 2, but lower than in MC or MC+AT patients.CONCLUSION:Our study first demonstrates higher serum levels of CXCL11 chemokine in patients with MC than in HCV+ patients, and in particular in the presence of AT.
Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis / A., Antonelli; P., Fallahi; Ferrari, Silvia Martina; Sebastiani, Marco; Manfredi, Andreina Teresa; V., Mazzi; S., Fabiani; M., Centanni; S., Marchi; Ferri, Clodoveo. - In: MODERN RHEUMATOLOGY. - ISSN 1439-7595. - STAMPA. - 22(2011), pp. 659-667.
| Data di pubblicazione: | 2011 |
| Titolo: | Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis. |
| Autore/i: | A., Antonelli; P., Fallahi; Ferrari, Silvia Martina; Sebastiani, Marco; Manfredi, Andreina Teresa; V., Mazzi; S., Fabiani; M., Centanni; S., Marchi; Ferri, Clodoveo |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10165-011-0565-x |
| Rivista: | |
| Volume: | 22 |
| Pagina iniziale: | 659 |
| Pagina finale: | 667 |
| Codice identificativo ISI: | WOS:000308727000003 |
| Codice identificativo Scopus: | 2-s2.0-84870321280 |
| Codice identificativo Pubmed: | 22160826 |
| Citazione: | Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis / A., Antonelli; P., Fallahi; Ferrari, Silvia Martina; Sebastiani, Marco; Manfredi, Andreina Teresa; V., Mazzi; S., Fabiani; M., Centanni; S., Marchi; Ferri, Clodoveo. - In: MODERN RHEUMATOLOGY. - ISSN 1439-7595. - STAMPA. - 22(2011), pp. 659-667. |
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