Similarly to Epstein-Barr virus (EBV), the human herpesvirus-8 (HHV-8) is a γ-herpesvirus, recently recognized to be associated with the occurrence of rare B cell lymphomas and atypical lymphoproliferations, especially in the human immunodeficiency virus (HIV) infected subjects. Moreover, the human herpesvirus-6 (HHV-6), a β-herpesvirus, has been shown to be implicated in some non-malignant lymph node proliferations, such as the Rosai Dorfman disease, and in a proportion of Hodgkin's lymphoma cases. HHV-6 has a wide cellular tropism and it might play a role in the pathogenesis of a wide variety of human diseases, but given its ubiquity, disease associations are difficult to prove and its role in hematological malignancies is still controversial. The involvement of another β-herpesvirus, the human cytomegalovirus (HCMV), has not yet been proven in human cancer, even though recent findings have suggested its potential role in the development of CD4(+) large granular lymphocyte (LGL) lymphocytosis. Here, we review the current knowledge on the pathogenetic role of HHV-8 and human β-herpesviruses in human lymphoproliferative disorders.

β-HHVs and HHV-8 in Lymphoproliferative Disorders / Quadrelli, Chiara; Barozzi, Patrizia; Riva, Giovanni; Vallerini, Daniela; E., Zanetti; Potenza, Leonardo; Forghieri, Fabio; Luppi, Mario. - In: MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES. - ISSN 2035-3006. - ELETTRONICO. - 3:1(2011), pp. 1-10. [10.4084/MJHID.2011.043]

β-HHVs and HHV-8 in Lymphoproliferative Disorders.

QUADRELLI, Chiara;BAROZZI, Patrizia;RIVA, Giovanni;VALLERINI, Daniela;POTENZA, Leonardo;FORGHIERI, Fabio;LUPPI, Mario
2011

Abstract

Similarly to Epstein-Barr virus (EBV), the human herpesvirus-8 (HHV-8) is a γ-herpesvirus, recently recognized to be associated with the occurrence of rare B cell lymphomas and atypical lymphoproliferations, especially in the human immunodeficiency virus (HIV) infected subjects. Moreover, the human herpesvirus-6 (HHV-6), a β-herpesvirus, has been shown to be implicated in some non-malignant lymph node proliferations, such as the Rosai Dorfman disease, and in a proportion of Hodgkin's lymphoma cases. HHV-6 has a wide cellular tropism and it might play a role in the pathogenesis of a wide variety of human diseases, but given its ubiquity, disease associations are difficult to prove and its role in hematological malignancies is still controversial. The involvement of another β-herpesvirus, the human cytomegalovirus (HCMV), has not yet been proven in human cancer, even though recent findings have suggested its potential role in the development of CD4(+) large granular lymphocyte (LGL) lymphocytosis. Here, we review the current knowledge on the pathogenetic role of HHV-8 and human β-herpesviruses in human lymphoproliferative disorders.
2011
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1
1
10
β-HHVs and HHV-8 in Lymphoproliferative Disorders / Quadrelli, Chiara; Barozzi, Patrizia; Riva, Giovanni; Vallerini, Daniela; E., Zanetti; Potenza, Leonardo; Forghieri, Fabio; Luppi, Mario. - In: MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES. - ISSN 2035-3006. - ELETTRONICO. - 3:1(2011), pp. 1-10. [10.4084/MJHID.2011.043]
Quadrelli, Chiara; Barozzi, Patrizia; Riva, Giovanni; Vallerini, Daniela; E., Zanetti; Potenza, Leonardo; Forghieri, Fabio; Luppi, Mario
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