We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.

Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection / Guergnon, J; Dalmasso, C; Broet, P; Meyer, L; Westrop, Sj; Imami, N; Vicenzi, E; Morsica, G; Tinelli, M; Zanone Poma, B; Goujard, C; Potard, V; Gotch, Fm; Casoli, C; Cossarizza, Andrea; Macciardi, F; Debré, P; Delfraissy, Jf; Galli, M; Autran, B; Costagliola, D; Poli, G; Theodorou, I; Riva, A.. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - STAMPA. - 205:(2012), pp. 718-724. [10.1093/infdis/jir833]

Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection.

COSSARIZZA, Andrea;
2012-01-01

Abstract

We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.
205
718
724
Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection / Guergnon, J; Dalmasso, C; Broet, P; Meyer, L; Westrop, Sj; Imami, N; Vicenzi, E; Morsica, G; Tinelli, M; Zanone Poma, B; Goujard, C; Potard, V; Gotch, Fm; Casoli, C; Cossarizza, Andrea; Macciardi, F; Debré, P; Delfraissy, Jf; Galli, M; Autran, B; Costagliola, D; Poli, G; Theodorou, I; Riva, A.. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - STAMPA. - 205:(2012), pp. 718-724. [10.1093/infdis/jir833]
Guergnon, J; Dalmasso, C; Broet, P; Meyer, L; Westrop, Sj; Imami, N; Vicenzi, E; Morsica, G; Tinelli, M; Zanone Poma, B; Goujard, C; Potard, V; Gotch, Fm; Casoli, C; Cossarizza, Andrea; Macciardi, F; Debré, P; Delfraissy, Jf; Galli, M; Autran, B; Costagliola, D; Poli, G; Theodorou, I; Riva, A.
File in questo prodotto:
File Dimensione Formato  
2012 JID - Guergnon.pdf

non disponibili

Tipologia: Versione pubblicata dall'editore
Dimensione 269.51 kB
Formato Adobe PDF
269.51 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/701152
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 25
social impact