Treatment of N-allyl-N¢,N¢-dimethyl-2,2-dichlorohydrazides with CuCl/TMEDA in ethyl acetate35is a mild and easy method for preparing N-(dimethylamino)-2-pyrrolidinones. As the N-N bond in the lactamproducts can be easily and efficiently cleaved, this makesN-dimethylamino protection an attractive alternative toN-benzylic protection.
N,N-(dimethylamino)-2-pyrrolidinones from the rearrangement of N-allyl-N ',N '-dimethyl-2,2-dichlorohydrazides promoted by CuCl-N,N,N ',N '-tetramethylethylendiamine / Ghelfi, Franco; Parsons, Af. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 65:19(2000), pp. 6249-6253. [10.1021/jo0004153]
N,N-(dimethylamino)-2-pyrrolidinones from the rearrangement of N-allyl-N ',N '-dimethyl-2,2-dichlorohydrazides promoted by CuCl-N,N,N ',N '-tetramethylethylendiamine
GHELFI, Franco;
2000
Abstract
Treatment of N-allyl-N¢,N¢-dimethyl-2,2-dichlorohydrazides with CuCl/TMEDA in ethyl acetate35is a mild and easy method for preparing N-(dimethylamino)-2-pyrrolidinones. As the N-N bond in the lactamproducts can be easily and efficiently cleaved, this makesN-dimethylamino protection an attractive alternative toN-benzylic protection.
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