To investigate on the possible protective activity of glycyrrhizin (GL), 18β-glycyrrhetinic acid (18β-GA) and glabridin (GLB) against UVB radiation damage in human keratinocyte cultures the following assays were performed: MTT, Comet, ROS generation and Western blot test (for the p53 activation, BCL-2 regulation and PARP cleavage). Results: 18β-GA and GLB prevented direct and indirect DNA fragmentation avoiding apoptosis activation.in human keratinocytes.
18β-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures / Veratti, E., Rossi, T., Giudice, S., Benassi, L., Bertazzoni, G., Morini, D., Azzoni, P., Bruni, E., Giannetti, A., Magnoni, C.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 31:6(2011), pp. 2209-2215.
18β-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures
VERATTI, Eugenia;ROSSI, Tiziana;GIUDICE, Stefania;BENASSI, Luisa;BERTAZZONI, Giorgia;AZZONI, Paola;GIANNETTI, Alberto;MAGNONI, Cristina
2011
Abstract
To investigate on the possible protective activity of glycyrrhizin (GL), 18β-glycyrrhetinic acid (18β-GA) and glabridin (GLB) against UVB radiation damage in human keratinocyte cultures the following assays were performed: MTT, Comet, ROS generation and Western blot test (for the p53 activation, BCL-2 regulation and PARP cleavage). Results: 18β-GA and GLB prevented direct and indirect DNA fragmentation avoiding apoptosis activation.in human keratinocytes.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
