To investigate on the possible protective activity of glycyrrhizin (GL), 18β-glycyrrhetinic acid (18β-GA) and glabridin (GLB) against UVB radiation damage in human keratinocyte cultures the following assays were performed: MTT, Comet, ROS generation and Western blot test (for the p53 activation, BCL-2 regulation and PARP cleavage). Results: 18β-GA and GLB prevented direct and indirect DNA fragmentation avoiding apoptosis activation.in human keratinocytes.
18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures / Veratti, Eugenia; Rossi, Tiziana; Giudice, Stefania; Benassi, Luisa; Bertazzoni, Giorgia; Morini, D; Azzoni, Paola; Bruni, E; Giannetti, Alberto; Magnoni, Cristina. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 31:6(2011), pp. 2209-2215.
18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures.
VERATTI, Eugenia;ROSSI, Tiziana;GIUDICE, Stefania;BENASSI, Luisa;BERTAZZONI, Giorgia;AZZONI, Paola;GIANNETTI, Alberto;MAGNONI, Cristina
2011
Abstract
To investigate on the possible protective activity of glycyrrhizin (GL), 18β-glycyrrhetinic acid (18β-GA) and glabridin (GLB) against UVB radiation damage in human keratinocyte cultures the following assays were performed: MTT, Comet, ROS generation and Western blot test (for the p53 activation, BCL-2 regulation and PARP cleavage). Results: 18β-GA and GLB prevented direct and indirect DNA fragmentation avoiding apoptosis activation.in human keratinocytes.
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