The novel -diketo compound (3-acetyl-4-oxopentanoic acid) OPAA is here synthesized, completely characterized in the solid state by means of X-ray crystallography and in solution by potentiometry and 1H and 13C NMR spectroscopy. In the solid state, OPAA exhibits the di-keto (DK) structure, while in solution a strongly solvent dependent tautomeric equilibrium is observed. Theoretical ab-initio calculations employing DFT at B3LYP/6-311G** level and different methods of theoretical model chemistry (CBS-4M, G3MP2, CBS-QB3) are used to extensively investigate the tautomeric equilibrium in comparison with experimental data. Solvent effects are evaluated using CPCM continuum solvation method; among all implied methods, CBS-4M is the one that better predicts experimental data and is able to qualitatively describe tautomeric equilibrium in solution, allowing thermodynamic calculation of pKa. Furthermore a supermolecular solvent approach is used to better analyze solvent-solute interactions in order to forecast chemical properties.
Solvent effect on keto-enol tautomerism in a new B-diketone: a comparison between experimental data and different theoretical approaches / Ferrari, Erika; Saladini, Monica; Pignedoli, Francesca; Spagnolo, Ferdinando; Benassi, Rois. - In: NEW JOURNAL OF CHEMISTRY. - ISSN 1144-0546. - STAMPA. - 35(2011), pp. 2840-2847.
Data di pubblicazione: | 2011 |
Titolo: | Solvent effect on keto-enol tautomerism in a new B-diketone: a comparison between experimental data and different theoretical approaches. |
Autore/i: | Ferrari, Erika; Saladini, Monica; Pignedoli, Francesca; Spagnolo, Ferdinando; Benassi, Rois |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/c1nj20576e |
Rivista: | |
Volume: | 35 |
Pagina iniziale: | 2840 |
Pagina finale: | 2847 |
Codice identificativo ISI: | WOS:000297222300016 |
Codice identificativo Scopus: | 2-s2.0-84961978302 |
Citazione: | Solvent effect on keto-enol tautomerism in a new B-diketone: a comparison between experimental data and different theoretical approaches / Ferrari, Erika; Saladini, Monica; Pignedoli, Francesca; Spagnolo, Ferdinando; Benassi, Rois. - In: NEW JOURNAL OF CHEMISTRY. - ISSN 1144-0546. - STAMPA. - 35(2011), pp. 2840-2847. |
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