B-myb gene is expressed in neuroblastoma cells and down-regulated during differentiation. We used B-myb-transfected LAN-5 cells, which constitutively express high level of B-myb, to detect changes at phenotypic and morphological levels in basal and differentiation conditions. Our results demonstrate that the overexpression of B-myb markedly affects the cytoskeletal composition, the pattern of neurotransmitter enzymes and the extracellular matrix expression. In general, B-myb transfected neuroblastoma cells show a broad potentiality without a direction toward a specific neuroectodermal differentiation pathway. On the other hand, we confirm inhibition of the neuronal differentiation upon retinoic acid (RA) treatment of B-myb transfected cells. Furthermore, the ultrastructural analyses are supportive of a change in the metabolism in B-myb transfected cell treated with RA. Our data suggest that B-myb expression is compatible with an early phase of differentiation of neuroectodermal cells, but must be down-regulated for the completion of the differentiative programme.
Phenotypic and morphological characterization of neuroblastoma cells constitutively expressing B-myb / Scarpa, S; Negroni, A; Amendola, R; Signorelli, P; Calabretta, Bruno; Modesti, A; Raschellà, G.. - In: JOURNAL OF NEURO-ONCOLOGY. - ISSN 0167-594X. - STAMPA. - 31(1997), pp. 107-114.
Data di pubblicazione: | 1997 | |
Titolo: | Phenotypic and morphological characterization of neuroblastoma cells constitutively expressing B-myb. | |
Autore/i: | Scarpa, S; Negroni, A; Amendola, R; Signorelli, P; Calabretta, Bruno; Modesti, A; Raschellà, G. | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 31 | |
Pagina iniziale: | 107 | |
Pagina finale: | 114 | |
Codice identificativo ISI: | WOS:A1997WJ07400014 | |
Codice identificativo Scopus: | 2-s2.0-0031047653 | |
Codice identificativo Pubmed: | 9049836 | |
Citazione: | Phenotypic and morphological characterization of neuroblastoma cells constitutively expressing B-myb / Scarpa, S; Negroni, A; Amendola, R; Signorelli, P; Calabretta, Bruno; Modesti, A; Raschellà, G.. - In: JOURNAL OF NEURO-ONCOLOGY. - ISSN 0167-594X. - STAMPA. - 31(1997), pp. 107-114. | |
Tipologia | Articolo su rivista |
File in questo prodotto:
Pubblicazioni consigliate

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris