Although patients with essential thrombocythaemia (ET) do not have the Philadelphia chromosome t(9;22), which defines chronic myelocytic leukaemia, the chimeric BCR-ABL transcript mRNA from this translocation has been identified in patients with clinically typical essential thrombocythaemia”.These findings have been detected, by D Blickstein and colleagues2 in 48% of 25 patients negative for the Philadelphia chromosome who had essential thrombocythaemia, investigated by two-step nested RT-PCR. Some workers have not, however, been able to confirm these data by the same technique, in 18 and 20 such patients, respectively.  and  Moreover, others have shown the absence of the chimeric transcript in 41 patients with essential thrombocythaemia studied by the fluoresence in-situ hybridisation with a BCR-ABL probe.5We investigated 112 patients who had essential thrombocythaemia with long follow-up, by RT-PCR, and detected the BCR-ABL transcript in only one patient who progressed to myeloid blastic crisis 12 years after diagnosis. Actually, whether essential-thrombocythaemia patients negative for the Philadelphia chromosome express the BCR-ABL transcript has been a matter of controversy for several years. In studies, the apparent essential thrombocythaemia carrying the Philadelphia anomaly, cytogenetically or molecularly should probably be considered as a variant of chronic myelocytic leukaemia with thrombocytosis and often long survival, with obvious clinical and therapeutical implications.
|Anno di pubblicazione:||2000|
|Titolo:||Gestational thrombocytopenia - Reply|
|Autori:||Emilia G; Luppi M; Marasca R; Torelli G|
|Appare nelle tipologie:||Articolo su rivista|
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