PURPOSE: Estrogens inhibit adrenomedullary catecholamine release and catecholamine-mediated responses to stress. We examined whether estrogen supplementation reduces the sympathoadrenal response to mental stress in postmenopausal women. MATERIALS AND METHODS: We compared the effects of 3-week treatment with transdermal 17-beta-estradiol and placebo in 10 postmenopausal women using a randomized, blinded, crossover design. We measured plasma catecholamine levels and the cardiovascular and metabolic responses to a 15-minute stress with mental arithmetic. Treatments were compared using repeated measures analysis of variance. RESULTS: During placebo treatment, mean (+/- SD) epinephrine levels reached a peak of 431 +/- 135 pmol/liter after 15 minutes of stress; the epinephrine response was blunted during estradiol treatment, with a peak of 357 +/- 77 pmol/liter (P <0.05). Estradiol also blunted the diastolic blood pressure response to stress (baseline levels of 78 +/- 15 mm Hg vs peak of 90 +/- 6 mm Hg during placebo; baseline of 80 +/- 8 mm Hg vs peak of 84 +/- 6 mm Hg during estradiol; P <0.05). Estradiol treatment also blunted the decrease in the standard deviation of the mean of the electrocardiographic RR intervals and the increase in the ratio between the low-frequency and high-frequency bandwidths. CONCLUSION: We observed a moderate, although significant, reduction in markers of the stress response to mental arithmetic in postmenopausal women treated with transdermal 17-beta-estradiol. Am J Med. 2000;109:463-468.

The effects of transdermal estradiol on the response to mental stress in postmenopausal women: A randomized trial / Ceresini, G; Freddi, M; Morganti, S; Rebecchi, I; Modena, Ab; Rinaldi, M; Manca, C; Amaducci, A; DEL RIO, Graziano; Valenti, G.. - In: THE AMERICAN JOURNAL OF MEDICINE. - ISSN 0002-9343. - 109:(2000), pp. 463-468.

The effects of transdermal estradiol on the response to mental stress in postmenopausal women: A randomized trial

DEL RIO, Graziano;
2000-01-01

Abstract

PURPOSE: Estrogens inhibit adrenomedullary catecholamine release and catecholamine-mediated responses to stress. We examined whether estrogen supplementation reduces the sympathoadrenal response to mental stress in postmenopausal women. MATERIALS AND METHODS: We compared the effects of 3-week treatment with transdermal 17-beta-estradiol and placebo in 10 postmenopausal women using a randomized, blinded, crossover design. We measured plasma catecholamine levels and the cardiovascular and metabolic responses to a 15-minute stress with mental arithmetic. Treatments were compared using repeated measures analysis of variance. RESULTS: During placebo treatment, mean (+/- SD) epinephrine levels reached a peak of 431 +/- 135 pmol/liter after 15 minutes of stress; the epinephrine response was blunted during estradiol treatment, with a peak of 357 +/- 77 pmol/liter (P <0.05). Estradiol also blunted the diastolic blood pressure response to stress (baseline levels of 78 +/- 15 mm Hg vs peak of 90 +/- 6 mm Hg during placebo; baseline of 80 +/- 8 mm Hg vs peak of 84 +/- 6 mm Hg during estradiol; P <0.05). Estradiol treatment also blunted the decrease in the standard deviation of the mean of the electrocardiographic RR intervals and the increase in the ratio between the low-frequency and high-frequency bandwidths. CONCLUSION: We observed a moderate, although significant, reduction in markers of the stress response to mental arithmetic in postmenopausal women treated with transdermal 17-beta-estradiol. Am J Med. 2000;109:463-468.
109
463
468
The effects of transdermal estradiol on the response to mental stress in postmenopausal women: A randomized trial / Ceresini, G; Freddi, M; Morganti, S; Rebecchi, I; Modena, Ab; Rinaldi, M; Manca, C; Amaducci, A; DEL RIO, Graziano; Valenti, G.. - In: THE AMERICAN JOURNAL OF MEDICINE. - ISSN 0002-9343. - 109:(2000), pp. 463-468.
Ceresini, G; Freddi, M; Morganti, S; Rebecchi, I; Modena, Ab; Rinaldi, M; Manca, C; Amaducci, A; DEL RIO, Graziano; Valenti, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/6935
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