Staphylococcus aureus is a leading cause of community-acquired infections and healthcare-associated infections.Epidemiological data are useful for understanding the dynamics of the diffusion of this pathogen, and to plan controlactivities and monitor their effi cacy. Methods: S. aureus isolates were collected in 13 public hospital laboratories of Emilia-Romagna (northern Italy region) during February – March 2009; phenotypic and molecular characterizations of these isolateswere performed. Results: The study sample included 267 isolates, 57 from blood, 81 from respiratory tract, and 129from wounds; 106 (40%) were methicillin-resistant S. aureus (MRSA). MRSA showed a limited number of circulating cloneswith 2 predominant spa types – t008 and t041 – accounting for 36% and 27% of MRSA isolates, respectively. The t041 typehad a higher prevalence of antimicrobial resistance compared to other spa types and accounted for most of the retrievedhetero-vancomycin-intermediate S. aureus (h-VISA), while t008 was more frequently detected in non-hospital isolates. Ahigher degree of genetic diversity was observed in methicillin-susceptible S. aureus (MSSA), with no predominant clonesand low prevalence of antimicrobial resistance. The occurrence of community-acquired MRSA infection appears to be rarein Emilia-Romagna. Conclusions: In contrast to previous studies reporting Italian data, t008 was the most frequent spa typeamong MRSA isolates in Emilia-Romagna. The prevalence of antimicrobial resistance of different MRSA spa types couldinfl uence their ability to cause infections with hospital onset. The presence of only 2 major MRSA clones circulating inEmilia-Romagna increases the chances that a regional strategy aimed at MRSA prevention will be effective

Staphylococcus aureus in a northern Italian region: Phenotypic and molecular characterization / C., Gagliotti; M., Monaco; Sabia, Carla; R., Gargiulo; M., Sarti; A., Sanchini; M., Marchi; S., Ambretti; F., Calanca6; C., Carillo; A. P., Cipolloni; M., Confalonieri; C., Di Carlo; Maria F., Pedna; L., Ricci; M. R., Rossi; S., Storchi Incerti; G., Testa; C., Venturelli; A., Pantosti; M. L., Moro. - In: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. - ISSN 0036-5548. - ELETTRONICO. - 44:1(2012), pp. 24-28. [10.3109/00365548.2011.603744]

Staphylococcus aureus in a northern Italian region: Phenotypic and molecular characterization

SABIA, Carla;
2012

Abstract

Staphylococcus aureus is a leading cause of community-acquired infections and healthcare-associated infections.Epidemiological data are useful for understanding the dynamics of the diffusion of this pathogen, and to plan controlactivities and monitor their effi cacy. Methods: S. aureus isolates were collected in 13 public hospital laboratories of Emilia-Romagna (northern Italy region) during February – March 2009; phenotypic and molecular characterizations of these isolateswere performed. Results: The study sample included 267 isolates, 57 from blood, 81 from respiratory tract, and 129from wounds; 106 (40%) were methicillin-resistant S. aureus (MRSA). MRSA showed a limited number of circulating cloneswith 2 predominant spa types – t008 and t041 – accounting for 36% and 27% of MRSA isolates, respectively. The t041 typehad a higher prevalence of antimicrobial resistance compared to other spa types and accounted for most of the retrievedhetero-vancomycin-intermediate S. aureus (h-VISA), while t008 was more frequently detected in non-hospital isolates. Ahigher degree of genetic diversity was observed in methicillin-susceptible S. aureus (MSSA), with no predominant clonesand low prevalence of antimicrobial resistance. The occurrence of community-acquired MRSA infection appears to be rarein Emilia-Romagna. Conclusions: In contrast to previous studies reporting Italian data, t008 was the most frequent spa typeamong MRSA isolates in Emilia-Romagna. The prevalence of antimicrobial resistance of different MRSA spa types couldinfl uence their ability to cause infections with hospital onset. The presence of only 2 major MRSA clones circulating inEmilia-Romagna increases the chances that a regional strategy aimed at MRSA prevention will be effective
2012
gen-2012
44
1
24
28
Staphylococcus aureus in a northern Italian region: Phenotypic and molecular characterization / C., Gagliotti; M., Monaco; Sabia, Carla; R., Gargiulo; M., Sarti; A., Sanchini; M., Marchi; S., Ambretti; F., Calanca6; C., Carillo; A. P., Cipolloni; M., Confalonieri; C., Di Carlo; Maria F., Pedna; L., Ricci; M. R., Rossi; S., Storchi Incerti; G., Testa; C., Venturelli; A., Pantosti; M. L., Moro. - In: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. - ISSN 0036-5548. - ELETTRONICO. - 44:1(2012), pp. 24-28. [10.3109/00365548.2011.603744]
C., Gagliotti; M., Monaco; Sabia, Carla; R., Gargiulo; M., Sarti; A., Sanchini; M., Marchi; S., Ambretti; F., Calanca6; C., Carillo; A. P., Cipolloni;...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/691047
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