It has been suggested that nutritional manipulations during the first weeks of life can alter the development of the hypothalamic circuits involved in energy homeostasis. We studied the expression of a large number of the hypothalamic neuropeptide mRNAs that control body weight in mice that were overfed during breastfeeding (mice grown in a small litter, SL) and/or during adolescence (adolescent mice fed a high-fat diet, AHF). We also investigated possible alterations in mRNA levels after 50 days of a high-fat diet (high-fat challenge, CHF) at 19 weeks of age. Both SL and AHF conditions caused overweight during the period of developmental overfeeding. During adulthood, all of the mouse groups fed a CHF significantly gained weight in comparison with mice fed a low-fat diet, but the mice that had undergone both breast and adolescent overfeeding (SL-AHF-CHF mice) gained significantly more weight than the control CHF mice. Of the ten neuropeptide mRNAs studied, only neuropeptide Y (NPY) expression was decreased in all of the groups of developmentally overfed adult mice, but CHF during adulthood by itself induced a decrease in NPY, agouti-related protein (AgRP) and orexin (Orx) mRNA levels. Moreover, in the developmentally overfed CHF mice NPY, AgRP, galanin (GAL) and galanin-like peptide (GalP) mRNA levels significantly decreased in comparison with the control CHF mice. These results show that, during adulthood, hypothalamic neuropeptide systems are altered (NPY) and/or abnormally respond to a high-fat diet (NPY, AgRP, GAL and GalP) in mice overfed during critical developmental periods.
|Data di pubblicazione:||2011|
|Titolo:||Developmental overfeeding alters hypothalamic neuropeptide mRNA levels and response to a high-fat diet in adult mice|
|Autore/i:||Ferretti, Silvia; Fornari, Alice; Pedrazzi, Patrizia; Pellegrini, Massimo; Zoli, Michele|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.peptides.2011.06.001|
|Codice identificativo ISI:||WOS:000293679200003|
|Codice identificativo Scopus:||2-s2.0-79960321854|
|Codice identificativo Pubmed:||21683751|
|Citazione:||Developmental overfeeding alters hypothalamic neuropeptide mRNA levels and response to a high-fat diet in adult mice / Ferretti, Silvia; Fornari, Alice; Pedrazzi, Patrizia; Pellegrini, Massimo; Zoli, Michele. - In: PEPTIDES. - ISSN 0196-9781. - STAMPA. - 32(2011), pp. 1371-1383.|
|Tipologia||Articolo su rivista|
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