The expression of neutrophil gelatinase-associated lipocalin (NGAL) has been suggested to behave likea negative prognostic marker in stage I colorectal carcinoma. In the aim of clarifying whether its associationwith adverse outcome may descend from NGAL’s ability to regulate matrix metallo-proteinase-9(MMP-9), we analyzed the correlation, prognostic value, and association with neo-angiogenesis of NGALand MMP-9 immunohistochemical expression in a series of stage I colorectal carcinomas. A variableNGAL immunoexpression was demonstrated in 17 of the 48 analyzed cases with a significantly higherfrequency of positive cases among patients showing disease progression. NGAL expression was also positivelycorrelated with VEGF expression detected in the same cases. MMP-9 immunostaining was presentin the cytoplasm of the neoplastic cells in 30 cases; no significant correlations were evidenced with NGALexpression, as well as with the various clinico-pathological parameters or with progression of the colorectalcarcinomas. By contrast, NGAL expression was confirmed as a significant independent negativeprognostic marker related to a shorter disease-free survival in stage I colorectal carcinoma. Our preliminaryresults suggest that the association of NGAL with poor outcome might be independent from MMP-9regulation, thus highlighting its prognostic value in this neoplasia. If our findings are confirmed in furtheranalyses, NGAL assessment might be used in order to select those patients with a higher progression riskand to submit them to adjuvant therapies useful to prevent adverse outcome.
Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in stage I colorectal carcinoma / Barresi, V; Reggiani Bonetti, L; Di Gregorio, C; Vitarelli, E; PONZ DE LEON, Maurizio; Barresi, G.. - In: PATHOLOGY RESEARCH AND PRACTICE. - ISSN 0344-0338. - ELETTRONICO. - 207(2011), pp. 479-486.
Data di pubblicazione: | 2011 |
Titolo: | Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in stage I colorectal carcinoma. |
Autore/i: | Barresi, V; Reggiani Bonetti, L; Di Gregorio, C; Vitarelli, E; PONZ DE LEON, Maurizio; Barresi, G. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.prp.2011.05.012 |
Rivista: | |
Volume: | 207 |
Pagina iniziale: | 479 |
Pagina finale: | 486 |
Codice identificativo ISI: | WOS:000295384600004 |
Codice identificativo Scopus: | 2-s2.0-80051791317 |
Codice identificativo Pubmed: | 21726963 |
Citazione: | Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in stage I colorectal carcinoma / Barresi, V; Reggiani Bonetti, L; Di Gregorio, C; Vitarelli, E; PONZ DE LEON, Maurizio; Barresi, G.. - In: PATHOLOGY RESEARCH AND PRACTICE. - ISSN 0344-0338. - ELETTRONICO. - 207(2011), pp. 479-486. |
Tipologia | Articolo su rivista |
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