Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by C-13 urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 x 10(9)/L120 x 10(9)/L) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pylori infection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a nonimmunosuppressive treatment in some ITP patients.

Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura / Emilia, G; Longo, G; Luppi, Mario; Gandini, G; Morselli, M; Ferrar, L; Amarri, S; Cagossi, K; Torelli, Giuseppe. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 97(2001), pp. 812-814.

Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura

LUPPI, Mario;TORELLI, Giuseppe
2001

Abstract

Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by C-13 urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 x 10(9)/L120 x 10(9)/L) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pylori infection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a nonimmunosuppressive treatment in some ITP patients.
97
812
814
Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura / Emilia, G; Longo, G; Luppi, Mario; Gandini, G; Morselli, M; Ferrar, L; Amarri, S; Cagossi, K; Torelli, Giuseppe. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 97(2001), pp. 812-814.
Emilia, G; Longo, G; Luppi, Mario; Gandini, G; Morselli, M; Ferrar, L; Amarri, S; Cagossi, K; Torelli, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/6785
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