Apart from its antiretroviral effects, chloroquine (CQ) has other properties that may be of interest in setting of HIV infection. First, it is an anti-inflammatory drug and, second, it may help to prevent several AIDS-related opportunistic infections. Increasing experimental data demonstrate the ability of CQ to affect microbial growth both in vitro and in vivo, trough mechanisms only partially elucidated. This strongly suggests its use in combination with other drugs, as terapeutical agents in HIV positive patients, especially in countries with limited resources.
Experimental results on chloroquine and AIDS-related opportunistic infections / Boelaert, Jr; Appelberg, R; Gomes, Ms; Blasi, Elisabetta; Mazzolla, R; Grosset, J; Lounis, N; Soteriadou, K; Thiakaki, M; Taramelli, D; Tognazioli, C.. - In: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. - ISSN 1525-4135. - STAMPA. - 26:3(2001), pp. 300-301. [10.1097/00126334-200103010-00017]
Experimental results on chloroquine and AIDS-related opportunistic infections
BLASI, Elisabetta;
2001
Abstract
Apart from its antiretroviral effects, chloroquine (CQ) has other properties that may be of interest in setting of HIV infection. First, it is an anti-inflammatory drug and, second, it may help to prevent several AIDS-related opportunistic infections. Increasing experimental data demonstrate the ability of CQ to affect microbial growth both in vitro and in vivo, trough mechanisms only partially elucidated. This strongly suggests its use in combination with other drugs, as terapeutical agents in HIV positive patients, especially in countries with limited resources.
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