Abstract - To study the histogenetic recovery of hepatic lesions due to portal bacteremia, a complication of some clinical conditions, an experimental animal model had developed. Portal bacteremia was performed in 8-week rats and the morphological recovery of liver was histologically checked 1 to 6 days after bacteria inoculation. The major injuries, such as acute inflammatory exudate of the portobiliary spaces, piecemeal necrosis of muralium, micro-abscesses and areas of hepatocyte necrosis of the liver parenchyma, and thrombosis in the centrolobular vein were recorded 1 day after inoculation. Minimal signs of vacuolar degeneration, steatosis, necrosis areas, vessel congestion and focal hemosiderosis together with a small hepatocyte proliferative activity was instead appreciable with longer time. The results seem to suggest a role of vascular structures and Kupffer cells in the morphological repair. This experimental model could serve to understand better similar clinical hepatology conditions, such as portal bacteremia.Informazioni utili

Manenti, A., L., Trenti, L., Reggiani Bonetti, Davide, Zaffe e A., Botticelli. "Liver injury by experimental portal bacteremia: histogenetic recovery study in the rat" Working paper, WebMedCentral HEPATOLOGY - ISSN 2046-1690 - http://www.webmedcentral.com/, 2010.

Liver injury by experimental portal bacteremia: histogenetic recovery study in the rat

A. Manenti;L. Reggiani Bonetti;ZAFFE, Davide;
2010

Abstract

Abstract - To study the histogenetic recovery of hepatic lesions due to portal bacteremia, a complication of some clinical conditions, an experimental animal model had developed. Portal bacteremia was performed in 8-week rats and the morphological recovery of liver was histologically checked 1 to 6 days after bacteria inoculation. The major injuries, such as acute inflammatory exudate of the portobiliary spaces, piecemeal necrosis of muralium, micro-abscesses and areas of hepatocyte necrosis of the liver parenchyma, and thrombosis in the centrolobular vein were recorded 1 day after inoculation. Minimal signs of vacuolar degeneration, steatosis, necrosis areas, vessel congestion and focal hemosiderosis together with a small hepatocyte proliferative activity was instead appreciable with longer time. The results seem to suggest a role of vascular structures and Kupffer cells in the morphological repair. This experimental model could serve to understand better similar clinical hepatology conditions, such as portal bacteremia.Informazioni utili
Ottobre
http://www.webmedcentral.com/
Manenti, A.; Trenti, L.; Reggiani Bonetti, L.; Zaffe, Davide; Botticelli, A.
Manenti, A., L., Trenti, L., Reggiani Bonetti, Davide, Zaffe e A., Botticelli. "Liver injury by experimental portal bacteremia: histogenetic recovery study in the rat" Working paper, WebMedCentral HEPATOLOGY - ISSN 2046-1690 - http://www.webmedcentral.com/, 2010.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/670250
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