Bone defects healing by hyaluronic acid: preliminary results.

Aim. The aim of this study is to evaluate the capability ofHyaloss™ matrix (Fab – Fidia Advanced Biopolymers –Pd – Italy), a biomaterial based on hyaluronic acid, usedas organic scaffold in bone repair in post-extractive defects.Materials and methods: 20 post-extractive sockets wereselected, with similar size defects in the same patientand in the same hemiarch. Hyaluronic acid with high molecularweight (Hyaloss™ matrix, Fab – Pd – Italy) wasmixed with autologous bone obtained using Safescraper® curve (Meta – Re – Italy) to repair post-extractivesites. Safescraper® is a cutting edge system thatallows to the collection of autologous bone withoutusing traditional, incision-based collection techniques,which could cause discomfort to the patient.Results: Clinical and hystological evaluations were performed,four months after grafting, in the maxilla and inthe mandible. From a clinical point of view Hyaloss™matrix mixed with autologous bone and patient’s bloodbecomes a substance similar to gel, which is easy to insertin to the defect. From a hystological point of view, inthe treated site there is the presence of an erosive activity,with accelerated angiogenetic and bone remodellingactivities.Conclusions: The preliminary results show an accelerationof the bone deposit process and of its remodellingdue to the presence of Hyaloss™ matrix, which, from a clinical point of view, improves the handling and applicationof the bone matrix inside the defects and, from ahystologic point of view makes it possible to obtainbone regeneration in less time when it is used with autologousbone.