Unfolding turns immobilized cytochrome c into a His–His ligated form endowed with catalytic activity towards O2, which is absent in the native protein. Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress.
Immobilized unfolded cytochrome c acts as a catalyst for dioxygen reduction / Tavagnacco, Claudio; Monari, Stefano; Ranieri, Antonio; Bortolotti, Carlo Augusto; Peressini, Silvia; Borsari, Marco. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - ELETTRONICO. - 47:(2011), pp. 11122-11124. [10.1039/c1cc13854e]
Immobilized unfolded cytochrome c acts as a catalyst for dioxygen reduction
TAVAGNACCO, CLAUDIO;MONARI, Stefano;RANIERI, Antonio;BORTOLOTTI, Carlo Augusto;PERESSINI, SILVIA;BORSARI, Marco
2011
Abstract
Unfolding turns immobilized cytochrome c into a His–His ligated form endowed with catalytic activity towards O2, which is absent in the native protein. Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress.
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