Objectives: To prospectively compare clinical breast examination, mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (MRI) in a multicenter surveillance of high-risk women.Materials and Methods: We enrolled asymptomatic women aged ≥25: BRCA mutation carriers; first-degree relatives of BRCA mutation carriers, and women with strong family history of breast/ovarian cancer, including those with previous personal breast cancer.Results: A total of 18 centers enrolled 501 women and performed 1592 rounds (3.2 rounds/woman). Forty-nine screen-detected and 3 interval cancers were diagnosed: 44 invasive, 8 ductal carcinoma in situ; only 4 pT2 stage; 32 G3 grade. Of 39 patients explored for nodal status, 28 (72%) were negative. Incidence per year-woman resulted 3.3% overall, 2.1% <50, and 5.4% ≥50 years (P < 0.001), 4.3% in women with previous personal breast cancer and 2.5% in those without (P = 0.045). MRI was more sensitive (91%) than clinical breast examination (18%), mammography (50%), ultrasonography (52%), or mammography plus ultrasonography (63%) (P < 0.001). Specificity ranged 96% to 99%, positive predictive value 53% to 71%, positive likelihood ratio 24 to 52 (P not significant). MRI showed significantly better negative predictive value (99.6) and negative likelihood ratio (0.09) than those of the other modalities. At receiver operating characteristic analysis, the area under the curve of MRI (0.97) was significantly higher than that of mammography (0.83) or ultrasonography (0.82) and not significantly increased when MRI was combined with mammography and/or ultrasonography. Of 52 cancers, 16 (31%) were diagnosed only by MRI, 8 of 21 (38%) in women <50, and 8 of 31 (26%) in women ≥50 years of age.Conclusion: MRI largely outperformed mammography, ultrasonography, and their combination for screening high-risk women below and over 50.

Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (the high breast cancer risk italian 1 study): final results / Sardanelli, F.; Podo, F.; Santoro, F.; Manoukian, S.; Bergonzi, S.; Trecate, G.; Vergnaghi, D.; Federico, Massimo; Cortesi, L.; Corcione, S.; Morassut, S.; Di Maggio, C.; Cilotti, A.; Martincich, L.; Calabrese, M.; Zuiani, C.; Preda, L.; Bonanni, B.; Carbonaro, L. A.; Contegiacomo, A.; Panizza, P.; Di Cesare, E.; Savarese, A.; Crecco, M.; Turchetti, D.; Tonutti, M.; Belli, P.; Maschio, A. D.. - In: INVESTIGATIVE RADIOLOGY. - ISSN 0020-9996. - ELETTRONICO. - 46 (2):(2011), pp. 94-105. [10.1097/RLI.0b013e3181f3fcdf]

Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (the high breast cancer risk italian 1 study): final results.

FEDERICO, Massimo;
2011-01-01

Abstract

Objectives: To prospectively compare clinical breast examination, mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (MRI) in a multicenter surveillance of high-risk women.Materials and Methods: We enrolled asymptomatic women aged ≥25: BRCA mutation carriers; first-degree relatives of BRCA mutation carriers, and women with strong family history of breast/ovarian cancer, including those with previous personal breast cancer.Results: A total of 18 centers enrolled 501 women and performed 1592 rounds (3.2 rounds/woman). Forty-nine screen-detected and 3 interval cancers were diagnosed: 44 invasive, 8 ductal carcinoma in situ; only 4 pT2 stage; 32 G3 grade. Of 39 patients explored for nodal status, 28 (72%) were negative. Incidence per year-woman resulted 3.3% overall, 2.1% <50, and 5.4% ≥50 years (P < 0.001), 4.3% in women with previous personal breast cancer and 2.5% in those without (P = 0.045). MRI was more sensitive (91%) than clinical breast examination (18%), mammography (50%), ultrasonography (52%), or mammography plus ultrasonography (63%) (P < 0.001). Specificity ranged 96% to 99%, positive predictive value 53% to 71%, positive likelihood ratio 24 to 52 (P not significant). MRI showed significantly better negative predictive value (99.6) and negative likelihood ratio (0.09) than those of the other modalities. At receiver operating characteristic analysis, the area under the curve of MRI (0.97) was significantly higher than that of mammography (0.83) or ultrasonography (0.82) and not significantly increased when MRI was combined with mammography and/or ultrasonography. Of 52 cancers, 16 (31%) were diagnosed only by MRI, 8 of 21 (38%) in women <50, and 8 of 31 (26%) in women ≥50 years of age.Conclusion: MRI largely outperformed mammography, ultrasonography, and their combination for screening high-risk women below and over 50.
46 (2)
94
105
Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (the high breast cancer risk italian 1 study): final results / Sardanelli, F.; Podo, F.; Santoro, F.; Manoukian, S.; Bergonzi, S.; Trecate, G.; Vergnaghi, D.; Federico, Massimo; Cortesi, L.; Corcione, S.; Morassut, S.; Di Maggio, C.; Cilotti, A.; Martincich, L.; Calabrese, M.; Zuiani, C.; Preda, L.; Bonanni, B.; Carbonaro, L. A.; Contegiacomo, A.; Panizza, P.; Di Cesare, E.; Savarese, A.; Crecco, M.; Turchetti, D.; Tonutti, M.; Belli, P.; Maschio, A. D.. - In: INVESTIGATIVE RADIOLOGY. - ISSN 0020-9996. - ELETTRONICO. - 46 (2):(2011), pp. 94-105. [10.1097/RLI.0b013e3181f3fcdf]
Sardanelli, F.; Podo, F.; Santoro, F.; Manoukian, S.; Bergonzi, S.; Trecate, G.; Vergnaghi, D.; Federico, Massimo; Cortesi, L.; Corcione, S.; Morassut, S.; Di Maggio, C.; Cilotti, A.; Martincich, L.; Calabrese, M.; Zuiani, C.; Preda, L.; Bonanni, B.; Carbonaro, L. A.; Contegiacomo, A.; Panizza, P.; Di Cesare, E.; Savarese, A.; Crecco, M.; Turchetti, D.; Tonutti, M.; Belli, P.; Maschio, A. D.
File in questo prodotto:
File Dimensione Formato  
00004424-201102000-00003.pdf

non disponibili

Tipologia: Versione pubblicata dall'editore
Dimensione 1.45 MB
Formato Adobe PDF
1.45 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/662445
Citazioni
  • ???jsp.display-item.citation.pmc??? 63
  • Scopus 248
  • ???jsp.display-item.citation.isi??? 216
social impact