Chronic Obstructive Pulmonary Disease (COPD) has been recently recognized a condition involving not only the lungs. The presence of common factors in COPD and in other chronic extrapulmonary diseases, as well as the co-existence of these conditions in the same adult individual, support the hypothesis of a shared pathogenetic pathway.We will here review the interplay role between coexisting COPD and Metabolic Syndrome (MS), based on the most updated knowledge we will discuss this clinical condition from the definition, to the pathophysiology, and to the clinical implications.Basically, MS is more likely to be present in a COPD patients, and increased levels of circulatory pro-inflammatory proteins from both the lung and the adipose tissue coincide in these patients.Actually, the relative impact of the coexisting COPD and MS may depend on several factors: mainly the presence of physical inactivity and of systemic inflammation related to smoking habit,sedentary lifestyle, airways inflammation and obstruction, adipose tissue and inflammatory markers activation. More studies will be required to elucidate the association between COPD and MS andto formulate individualized management approaches for this specific disease phenotype.

COPD and metabolic syndrome: an intriguing association / Clini, Enrico; E., Crisafulli; A., Radaeli; M., Malerba. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - ELETTRONICO. - 8(4):(2013), pp. 283-289. [10.1007/s11739-011-0700-x]

COPD and metabolic syndrome: an intriguing association

CLINI, Enrico;
2013

Abstract

Chronic Obstructive Pulmonary Disease (COPD) has been recently recognized a condition involving not only the lungs. The presence of common factors in COPD and in other chronic extrapulmonary diseases, as well as the co-existence of these conditions in the same adult individual, support the hypothesis of a shared pathogenetic pathway.We will here review the interplay role between coexisting COPD and Metabolic Syndrome (MS), based on the most updated knowledge we will discuss this clinical condition from the definition, to the pathophysiology, and to the clinical implications.Basically, MS is more likely to be present in a COPD patients, and increased levels of circulatory pro-inflammatory proteins from both the lung and the adipose tissue coincide in these patients.Actually, the relative impact of the coexisting COPD and MS may depend on several factors: mainly the presence of physical inactivity and of systemic inflammation related to smoking habit,sedentary lifestyle, airways inflammation and obstruction, adipose tissue and inflammatory markers activation. More studies will be required to elucidate the association between COPD and MS andto formulate individualized management approaches for this specific disease phenotype.
8(4)
283
289
COPD and metabolic syndrome: an intriguing association / Clini, Enrico; E., Crisafulli; A., Radaeli; M., Malerba. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - ELETTRONICO. - 8(4):(2013), pp. 283-289. [10.1007/s11739-011-0700-x]
Clini, Enrico; E., Crisafulli; A., Radaeli; M., Malerba
File in questo prodotto:
File Dimensione Formato  
Clini (COPD and metabolic sindrome- 2013).pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 251.67 kB
Formato Adobe PDF
251.67 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/661238
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 44
  • ???jsp.display-item.citation.isi??? 37
social impact