Cidofovir is an antiviral drug active as antitumoral agent a high doses against the Primary Effusion Lymphoma, a herpesvirus HHV8-associated B-cell lymphoma. A novel polymeric/lipidic hybrid system, consisting in a specific combination of biocompatible materials, capable to build a crossbred betweenpolymeric particles and liposomes were prepared and used to stabilize and deliver the drug, unsuccessfully formulated into several types of carriers. This innovative cidofovir-delivering system has structurally been characterized in comparison to multilamellar liposomes and polymeric particles, and then testedfor antitumoral efficacy against tumor cells (BCBL-1 cell line). The results demonstrated the improving of drug stability and encapsulation efficiency and suggested that polymeric/lipidic hybrid system could be promising to improve the antitumoral effect of cidofovir even at lower doses.

Novel polymeric/lipidic hybrid systems (PLHs) for effective Cidofovir delivery: preparation, characterization and comparative in vitro study with polymeric particles and liposomes / Belletti, Daniela; Riva, Giovanni; Tosi, Giovanni; Forni, Flavio; Barozzi, Patrizia; Luppi, Mario; Vandelli, Maria Angela; Ruozi, Barbara. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 413(2011), pp. 220-228. [10.1016/j.ijpharm.2011.04.025]

Novel polymeric/lipidic hybrid systems (PLHs) for effective Cidofovir delivery: preparation, characterization and comparative in vitro study with polymeric particles and liposomes

BELLETTI, Daniela;RIVA, Giovanni;TOSI, Giovanni;FORNI, Flavio;BAROZZI, Patrizia;LUPPI, Mario;VANDELLI, Maria Angela;RUOZI, Barbara
2011

Abstract

Cidofovir is an antiviral drug active as antitumoral agent a high doses against the Primary Effusion Lymphoma, a herpesvirus HHV8-associated B-cell lymphoma. A novel polymeric/lipidic hybrid system, consisting in a specific combination of biocompatible materials, capable to build a crossbred betweenpolymeric particles and liposomes were prepared and used to stabilize and deliver the drug, unsuccessfully formulated into several types of carriers. This innovative cidofovir-delivering system has structurally been characterized in comparison to multilamellar liposomes and polymeric particles, and then testedfor antitumoral efficacy against tumor cells (BCBL-1 cell line). The results demonstrated the improving of drug stability and encapsulation efficiency and suggested that polymeric/lipidic hybrid system could be promising to improve the antitumoral effect of cidofovir even at lower doses.
413
220
228
Novel polymeric/lipidic hybrid systems (PLHs) for effective Cidofovir delivery: preparation, characterization and comparative in vitro study with polymeric particles and liposomes / Belletti, Daniela; Riva, Giovanni; Tosi, Giovanni; Forni, Flavio; Barozzi, Patrizia; Luppi, Mario; Vandelli, Maria Angela; Ruozi, Barbara. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 413(2011), pp. 220-228. [10.1016/j.ijpharm.2011.04.025]
Belletti, Daniela; Riva, Giovanni; Tosi, Giovanni; Forni, Flavio; Barozzi, Patrizia; Luppi, Mario; Vandelli, Maria Angela; Ruozi, Barbara
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/652039
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