A mathematical model is proposed which is able to describe the most important features of cell differ- entiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be sub ject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes.
A dynamical model of genetic networks for cell differentiation / Villani, Marco; Barbieri, Alessia; Serra, Roberto. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 6:(2011), pp. e17703-nd. [10.1371/journal.pone.0017703]
A dynamical model of genetic networks for cell differentiation
VILLANI, Marco;BARBIERI, ALESSIA;SERRA, Roberto
2011
Abstract
A mathematical model is proposed which is able to describe the most important features of cell differ- entiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be sub ject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes.File | Dimensione | Formato | |
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