A mathematical model is proposed which is able to describe the most important features of cell differ- entiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be sub ject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes.

A dynamical model of genetic networks for cell differentiation / Villani, Marco; Barbieri, Alessia; Serra, Roberto. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 6:(2011), pp. e17703-nd. [10.1371/journal.pone.0017703]

A dynamical model of genetic networks for cell differentiation

VILLANI, Marco;BARBIERI, ALESSIA;SERRA, Roberto
2011

Abstract

A mathematical model is proposed which is able to describe the most important features of cell differ- entiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be sub ject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes.
2011
6
e17703
nd
A dynamical model of genetic networks for cell differentiation / Villani, Marco; Barbieri, Alessia; Serra, Roberto. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 6:(2011), pp. e17703-nd. [10.1371/journal.pone.0017703]
Villani, Marco; Barbieri, Alessia; Serra, Roberto
File in questo prodotto:
File Dimensione Formato  
journal.pone.0017703.pdf

Open access

Descrizione: Articolo principale
Tipologia: Versione pubblicata dall'editore
Dimensione 397.13 kB
Formato Adobe PDF
397.13 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/649673
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 63
  • ???jsp.display-item.citation.isi??? 50
social impact