Neurotrophic factors (NTFs) represent one of the most stimulating challenge in neurodegenerative diseases, due to their potential in neurorestoring and neuroprotection. Despite the large number of proofs-of-concept and evidences of their activity, most of the clinical trials, mainly regarding Parkinson’s Disease and Alzheimer Disease, demonstrated several failures of the therapeutic intervention.A large number of researches were conducted on this hot topic of neuroscience, clearly evidencing the advantages of NTFs approach, but evidencing the major limitations in its application. The inability in crossing the Blood-Brain Barrier and the lack of selectivity actually represent some of the most highlighted limits of NTFs-based therapy. In this review, beside an overview of NTFs activity versus the main neuropathological disorders, a summary of the most relevant approaches, from invasive to non-invasive strategies, applied for improving NTFs delivery to the Central Nervous Systems is critically considered and evaluated.

NEUROTROPHIC FACTORS AND NEURODEGENERATIVE DISEASES: A DELIVERY ISSUE / Ruozi, Barbara; Belletti, Daniela; Bondioli, Lucia; A., De Vita; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni. - STAMPA. - 102:(2011), pp. 207-247. [10.1016/B978-0-12-386986-9.00009-0]

NEUROTROPHIC FACTORS AND NEURODEGENERATIVE DISEASES: A DELIVERY ISSUE

RUOZI, Barbara;BELLETTI, Daniela;BONDIOLI, Lucia;FORNI, Flavio;VANDELLI, Maria Angela;TOSI, Giovanni
2011

Abstract

Neurotrophic factors (NTFs) represent one of the most stimulating challenge in neurodegenerative diseases, due to their potential in neurorestoring and neuroprotection. Despite the large number of proofs-of-concept and evidences of their activity, most of the clinical trials, mainly regarding Parkinson’s Disease and Alzheimer Disease, demonstrated several failures of the therapeutic intervention.A large number of researches were conducted on this hot topic of neuroscience, clearly evidencing the advantages of NTFs approach, but evidencing the major limitations in its application. The inability in crossing the Blood-Brain Barrier and the lack of selectivity actually represent some of the most highlighted limits of NTFs-based therapy. In this review, beside an overview of NTFs activity versus the main neuropathological disorders, a summary of the most relevant approaches, from invasive to non-invasive strategies, applied for improving NTFs delivery to the Central Nervous Systems is critically considered and evaluated.
NEW PERSPECTIVES OF CENTRAL NERVOUS SYSTEM INJURY AND NEUROPROTECTION
978-0-12-386986-9
ELSEVIER ACADEMIC PRESS INC
STATI UNITI D'AMERICA
NEUROTROPHIC FACTORS AND NEURODEGENERATIVE DISEASES: A DELIVERY ISSUE / Ruozi, Barbara; Belletti, Daniela; Bondioli, Lucia; A., De Vita; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni. - STAMPA. - 102:(2011), pp. 207-247. [10.1016/B978-0-12-386986-9.00009-0]
Ruozi, Barbara; Belletti, Daniela; Bondioli, Lucia; A., De Vita; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/649197
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