IntroductionNanocarriers are considered as the most innovative drug delivery systems, due to their high potential in drug protection, delivery and mainly targeting to the diseased site; unfortunately, their applicability is mainly hampered by their uptake due to macrophagic recognition and lack of specificity if not properly engineered. Areas coveredSialic acid (SA) and its derivatives was deeply studied in order to govern the stealthness of carriers or, more recently, to act as targeting moiety. In this review, we summarized the most outstanding researches (in vitro and in vivo) dealing with the use of SAs or derivatives to modify the carriers surface in order to achieve targeted or stealth nanosystems. Moreover, we also consider the application of SA or derivatives as modifiers used for cancer targeting and therapy and for recognition purposes.Expert OpinionThe application of SA-based strategy for nanocarriers engineering represents one of the most stimulating challenge in drug delivery and drug targeting. The in vivo and in vitro ouptuts on stealth or targeted nanocarriers, modified with different kinds of SAs or SA-derivative, highlighted the great potential of this approach, both evidencing the advantages (stealth properties, targeting ability, cancer inhibition, viral and inflammation recognition, brain targeting) and the possible disadvantages (i.e. presence of possible multi-target side effects outputs), suggesting further investigations on this strategy.

Sialic Acid as a potential approach for the protection and targeting of nanocarriers / Bondioli, Lucia; Ruozi, Barbara; Belletti, Daniela; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni. - In: EXPERT OPINION ON DRUG DELIVERY. - ISSN 1742-5247. - STAMPA. - 8:(2011), pp. 921-937. [10.1517/17425247.2011.577061]

Sialic Acid as a potential approach for the protection and targeting of nanocarriers

BONDIOLI, Lucia;RUOZI, Barbara;BELLETTI, Daniela;FORNI, Flavio;VANDELLI, Maria Angela;TOSI, Giovanni
2011

Abstract

IntroductionNanocarriers are considered as the most innovative drug delivery systems, due to their high potential in drug protection, delivery and mainly targeting to the diseased site; unfortunately, their applicability is mainly hampered by their uptake due to macrophagic recognition and lack of specificity if not properly engineered. Areas coveredSialic acid (SA) and its derivatives was deeply studied in order to govern the stealthness of carriers or, more recently, to act as targeting moiety. In this review, we summarized the most outstanding researches (in vitro and in vivo) dealing with the use of SAs or derivatives to modify the carriers surface in order to achieve targeted or stealth nanosystems. Moreover, we also consider the application of SA or derivatives as modifiers used for cancer targeting and therapy and for recognition purposes.Expert OpinionThe application of SA-based strategy for nanocarriers engineering represents one of the most stimulating challenge in drug delivery and drug targeting. The in vivo and in vitro ouptuts on stealth or targeted nanocarriers, modified with different kinds of SAs or SA-derivative, highlighted the great potential of this approach, both evidencing the advantages (stealth properties, targeting ability, cancer inhibition, viral and inflammation recognition, brain targeting) and the possible disadvantages (i.e. presence of possible multi-target side effects outputs), suggesting further investigations on this strategy.
8
921
937
Sialic Acid as a potential approach for the protection and targeting of nanocarriers / Bondioli, Lucia; Ruozi, Barbara; Belletti, Daniela; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni. - In: EXPERT OPINION ON DRUG DELIVERY. - ISSN 1742-5247. - STAMPA. - 8:(2011), pp. 921-937. [10.1517/17425247.2011.577061]
Bondioli, Lucia; Ruozi, Barbara; Belletti, Daniela; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni
File in questo prodotto:
File Dimensione Formato  
Bondioli et al., Exp Opin 2011.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 686.36 kB
Formato Adobe PDF
686.36 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/648975
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 27
social impact