Curcumin, an active ingredient in the traditional Ayurvedic herbal remedy [Curcuma longa L.], isnowadays also employed in western medicine for its pleiotropic activities, ranging from anticancer to itsfree radical scavenger ability. These features are related to curcumin’s function as a metal chelator,especially being selective for hard Lewis acids, such as Ga3+ which has interesting pharmacologicalactivities. We report the synthesis and characterization of a bioactive gel and mesoporous Ga-containing phospho-silicate glasses loaded with curcumin, in which, for the first time, coordinationchemistry was taken advantage of in designing novel drug delivery systems. In particular, it was foundthat: (i) there is a direct correlation between the external surface area and the amount of loadedcurcumin; (ii) the presence of Ga3+ species on the surface increases the quantity of drug moleculesuploaded and slows down their release in the biological medium (SBF), hinting at a coordination-likeinteraction between curcumin and the surface metal ions; (iii) curcumin molecules released in the SBFsolution stabilize Ga3+ ions, avoiding their precipitation.

The role of coordination chemistry in the development of innovative Gallium-based bioceramics: the case of Curcumin / Ferrari, Erika; Lusvardi, Gigliola; V., Aina; Malavasi, Gianluca; F., Fantini; C., Morterra; Pignedoli, Francesca; Saladini, Monica; Menabue, Ledi. - In: JOURNAL OF MATERIALS CHEMISTRY. - ISSN 0959-9428. - ELETTRONICO. - 21:(2011), pp. 5027-5037. [10.1039/C0JM03421E]

The role of coordination chemistry in the development of innovative Gallium-based bioceramics: the case of Curcumin

FERRARI, Erika;LUSVARDI, Gigliola;MALAVASI, Gianluca;PIGNEDOLI, FRANCESCA;SALADINI, Monica;MENABUE, Ledi
2011

Abstract

Curcumin, an active ingredient in the traditional Ayurvedic herbal remedy [Curcuma longa L.], isnowadays also employed in western medicine for its pleiotropic activities, ranging from anticancer to itsfree radical scavenger ability. These features are related to curcumin’s function as a metal chelator,especially being selective for hard Lewis acids, such as Ga3+ which has interesting pharmacologicalactivities. We report the synthesis and characterization of a bioactive gel and mesoporous Ga-containing phospho-silicate glasses loaded with curcumin, in which, for the first time, coordinationchemistry was taken advantage of in designing novel drug delivery systems. In particular, it was foundthat: (i) there is a direct correlation between the external surface area and the amount of loadedcurcumin; (ii) the presence of Ga3+ species on the surface increases the quantity of drug moleculesuploaded and slows down their release in the biological medium (SBF), hinting at a coordination-likeinteraction between curcumin and the surface metal ions; (iii) curcumin molecules released in the SBFsolution stabilize Ga3+ ions, avoiding their precipitation.
21
5027
5037
The role of coordination chemistry in the development of innovative Gallium-based bioceramics: the case of Curcumin / Ferrari, Erika; Lusvardi, Gigliola; V., Aina; Malavasi, Gianluca; F., Fantini; C., Morterra; Pignedoli, Francesca; Saladini, Monica; Menabue, Ledi. - In: JOURNAL OF MATERIALS CHEMISTRY. - ISSN 0959-9428. - ELETTRONICO. - 21:(2011), pp. 5027-5037. [10.1039/C0JM03421E]
Ferrari, Erika; Lusvardi, Gigliola; V., Aina; Malavasi, Gianluca; F., Fantini; C., Morterra; Pignedoli, Francesca; Saladini, Monica; Menabue, Ledi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/648900
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