BACKGROUND: Depression is a frequently observed and disabling condition in primary care, mainly treated by Primary Care Physicians with antidepressant drugs. Psychological interventions are recommended as first-line treatment by the most authoritative international guidelines but few evidences are available on their efficacy and effectiveness for mild depression.METHODS/DESIGN: This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling, a brief structured psychological intervention, to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression, had a score ≥ 13 on the 21-item Hamilton Depression Rating Scale, and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months, defined as a HDRS score ≤ 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment.DISCUSSION: This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated, by including a sample of patients with mild/moderate depression and by using different outcome measures.TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12608000479303.

Depression in primary care: interpersonal counseling vs selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design / Menchetti, M; Bortolotti, B; Rucci, P; Scocco, P; Bombi, A; Berardi, D; Affatati, V; Alberini, G; Baranzini, F; Bellino, S; Bellomo, A; Blasi, T; Bogetto, F; Bortolaso, P; Callegari, C; Carpiniello, B; Colombini, N; Contu, C; Croci, G; De Salvia, M; Diurni, M; Elisei, S; Ferretti, M; Fiore, P; Fusar Poli, P; Iuso, S; Lacalamita, A; La Ferla, T; Lia, L; Luciano, Cc; Magnani, M; Manganaro, D; Martinelli, V; Martino, I; Montaguti, Mb; Nespeca, C; Petito, A; Pinna, F; Piselli, M; Politi, P; Quartesan, R; Rella, A; Restaino, F; Rigatelli, Marco; Sciarini, P; Simoni, E; Succu, M; Tedeschini, E; Todarello, O; Vender, S; Zaccagni, L; Zizza, M.. - In: BMC PSYCHIATRY. - ISSN 1471-244X. - STAMPA. - 25:(2011), pp. 97-105. [10.1186/1471-244X-10-97]

Depression in primary care: interpersonal counseling vs selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design.

RIGATELLI, Marco;
2011

Abstract

BACKGROUND: Depression is a frequently observed and disabling condition in primary care, mainly treated by Primary Care Physicians with antidepressant drugs. Psychological interventions are recommended as first-line treatment by the most authoritative international guidelines but few evidences are available on their efficacy and effectiveness for mild depression.METHODS/DESIGN: This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling, a brief structured psychological intervention, to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression, had a score ≥ 13 on the 21-item Hamilton Depression Rating Scale, and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months, defined as a HDRS score ≤ 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment.DISCUSSION: This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated, by including a sample of patients with mild/moderate depression and by using different outcome measures.TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12608000479303.
25
97
105
Depression in primary care: interpersonal counseling vs selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design / Menchetti, M; Bortolotti, B; Rucci, P; Scocco, P; Bombi, A; Berardi, D; Affatati, V; Alberini, G; Baranzini, F; Bellino, S; Bellomo, A; Blasi, T; Bogetto, F; Bortolaso, P; Callegari, C; Carpiniello, B; Colombini, N; Contu, C; Croci, G; De Salvia, M; Diurni, M; Elisei, S; Ferretti, M; Fiore, P; Fusar Poli, P; Iuso, S; Lacalamita, A; La Ferla, T; Lia, L; Luciano, Cc; Magnani, M; Manganaro, D; Martinelli, V; Martino, I; Montaguti, Mb; Nespeca, C; Petito, A; Pinna, F; Piselli, M; Politi, P; Quartesan, R; Rella, A; Restaino, F; Rigatelli, Marco; Sciarini, P; Simoni, E; Succu, M; Tedeschini, E; Todarello, O; Vender, S; Zaccagni, L; Zizza, M.. - In: BMC PSYCHIATRY. - ISSN 1471-244X. - STAMPA. - 25:(2011), pp. 97-105. [10.1186/1471-244X-10-97]
Menchetti, M; Bortolotti, B; Rucci, P; Scocco, P; Bombi, A; Berardi, D; Affatati, V; Alberini, G; Baranzini, F; Bellino, S; Bellomo, A; Blasi, T; Bogetto, F; Bortolaso, P; Callegari, C; Carpiniello, B; Colombini, N; Contu, C; Croci, G; De Salvia, M; Diurni, M; Elisei, S; Ferretti, M; Fiore, P; Fusar Poli, P; Iuso, S; Lacalamita, A; La Ferla, T; Lia, L; Luciano, Cc; Magnani, M; Manganaro, D; Martinelli, V; Martino, I; Montaguti, Mb; Nespeca, C; Petito, A; Pinna, F; Piselli, M; Politi, P; Quartesan, R; Rella, A; Restaino, F; Rigatelli, Marco; Sciarini, P; Simoni, E; Succu, M; Tedeschini, E; Todarello, O; Vender, S; Zaccagni, L; Zizza, M.
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