The co-occurrence of myasthenia gravis (MG) and multiple sclerosis (MS) is rare, and in all the described cases MS had a relapsing-remitting course and the diseases had a benign clinical evolution. We describe herewith a patient with primary progressive MS (PPMS) and generalized MG with severe clinical course. This is the first report on a case of PPMS associated to MG. Studies on the histology and pathogenesis show that neurodegeneration is predominant over inflammation in PPMS, even if cellular and humoral immune-mediated mechanisms are thought to maintain a crucial importance in the development and progression of this form of disease. In the present case, the detection of cerebrospinal fluid IgM oligoclonal bands support the hypothesis of a possible role of antibody-mediated immunity in PPMS and suggest that humoral immunity may take part in the concomitant development of both MS and MG.

Primary progressive multiple sclerosis and generalized myasthenia gravis: an uncommon association / Bigliardi, Guido; Mandrioli, Jessica; F., Valzania; Nichelli, Paolo Frigio; N., Casula; Simone, ANNA MARIA; P., Sola. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 31:(2010), pp. 833-836. [10.1007/s10072-010-0358-6]

Primary progressive multiple sclerosis and generalized myasthenia gravis: an uncommon association

BIGLIARDI, Guido;MANDRIOLI, Jessica;NICHELLI, Paolo Frigio;SIMONE, ANNA MARIA;
2010

Abstract

The co-occurrence of myasthenia gravis (MG) and multiple sclerosis (MS) is rare, and in all the described cases MS had a relapsing-remitting course and the diseases had a benign clinical evolution. We describe herewith a patient with primary progressive MS (PPMS) and generalized MG with severe clinical course. This is the first report on a case of PPMS associated to MG. Studies on the histology and pathogenesis show that neurodegeneration is predominant over inflammation in PPMS, even if cellular and humoral immune-mediated mechanisms are thought to maintain a crucial importance in the development and progression of this form of disease. In the present case, the detection of cerebrospinal fluid IgM oligoclonal bands support the hypothesis of a possible role of antibody-mediated immunity in PPMS and suggest that humoral immunity may take part in the concomitant development of both MS and MG.
2010
31
833
836
Primary progressive multiple sclerosis and generalized myasthenia gravis: an uncommon association / Bigliardi, Guido; Mandrioli, Jessica; F., Valzania; Nichelli, Paolo Frigio; N., Casula; Simone, ANNA MARIA; P., Sola. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 31:(2010), pp. 833-836. [10.1007/s10072-010-0358-6]
Bigliardi, Guido; Mandrioli, Jessica; F., Valzania; Nichelli, Paolo Frigio; N., Casula; Simone, ANNA MARIA; P., Sola
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/648237
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