Rat thymocytes were stimulated with phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS) or with mixtures of two of these mitogens, added simultaneously to in vitro cultures. Four-five concentrations of first mitogen were matched with four-five concentrations of second mitogen, in all possible combinations. Synergistic effects were observed with LPS plus PHA and LPS plus PWM and inhibitory effects with PHA plus Con A and LPS plus Con A. The hypothesis is discussed that an inhibitory effects occurs when two mitogens react with identical or very similar receptors on the lymphocyte surface, while a synergistic effect is produced by two mitogens reacting with different receptors.

INHIBITION AND POTENTIATION OF T LYMPHOCYTE RESPONSE TO MITOGENS. STUDIES USIGN TWO MITOGENIC STIMULI SIMULTANEOUSLY / C., Franceschi; C., Cevolani; F., Licastro; Paolucci, Paolo; G., Prodi; P., Perocco. - In: ARCHIVIO DI SCIENZE BIOLOGICHE. - ISSN 0004-0169. - STAMPA. - 62:(1978), pp. 139-154.

INHIBITION AND POTENTIATION OF T LYMPHOCYTE RESPONSE TO MITOGENS. STUDIES USIGN TWO MITOGENIC STIMULI SIMULTANEOUSLY

PAOLUCCI, Paolo;
1978

Abstract

Rat thymocytes were stimulated with phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS) or with mixtures of two of these mitogens, added simultaneously to in vitro cultures. Four-five concentrations of first mitogen were matched with four-five concentrations of second mitogen, in all possible combinations. Synergistic effects were observed with LPS plus PHA and LPS plus PWM and inhibitory effects with PHA plus Con A and LPS plus Con A. The hypothesis is discussed that an inhibitory effects occurs when two mitogens react with identical or very similar receptors on the lymphocyte surface, while a synergistic effect is produced by two mitogens reacting with different receptors.
1978
62
139
154
INHIBITION AND POTENTIATION OF T LYMPHOCYTE RESPONSE TO MITOGENS. STUDIES USIGN TWO MITOGENIC STIMULI SIMULTANEOUSLY / C., Franceschi; C., Cevolani; F., Licastro; Paolucci, Paolo; G., Prodi; P., Perocco. - In: ARCHIVIO DI SCIENZE BIOLOGICHE. - ISSN 0004-0169. - STAMPA. - 62:(1978), pp. 139-154.
C., Franceschi; C., Cevolani; F., Licastro; Paolucci, Paolo; G., Prodi; P., Perocco
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