The immune competence of the T lymphocyte system was studied in 28 noninstitutionalized subjects with Down's syndrome (DS) and were compared with sex- and age-matched healthy controls. The ability of enriched T lymphocytes to respond to 3 different T cell stimulants revealed a selective impairment of T lymphocyte subset(s). Subjects with DS showed normal responsiveness in allogeneic mixed lymphocyte reactions, but their response to phytohemagglutinin and in autologous mixed lymphocyte reactions was severely impaired. Non-T cells from DS subjects stimulated equally well both normal and DS allogeneic T lymphocytes. The blood concentration of serum thymic factor in the majority of DS subjects was much lower than that found in age-matched healthy controls. These data support the hypothesis that a deficiency of the T-dependent regulatory system is an intrinsic feature of DS and confirm the precocious aging of the immune system in these subjects.
|Data di pubblicazione:||1981|
|Titolo:||Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome|
|Autore/i:||Franceschi C; Licastro F; Chiricolo M; Bonetti F; Zannotti M; Fabris N; Mocchegiani E; Fantini MP; Paolucci P; Masi M.|
|Codice identificativo ISI:||WOS:A1981LR85800018|
|Codice identificativo Scopus:||2-s2.0-0019450109|
|Citazione:||Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome / Franceschi C; Licastro F; Chiricolo M; Bonetti F; Zannotti M; Fabris N; Mocchegiani E; Fantini MP; Paolucci P; Masi M.. - In: JOURNAL OF IMMUNOLOGY. - ISSN 0022-1767. - ELETTRONICO. - 126(6)(1981), pp. 2161-2164.|
|Tipologia||Articolo su rivista|
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