Stress is a key determinant of binge eating (BE). Since Rhodiola rosea is known to modulate stress responses, its effect in a model of BE was investigated. BE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/re-feeding (for 4days 66% of the usual chow intake; for 4days food ad libitum) and acute stress on the test day (day 25). R. rosea dry extract (3% rosavin, 3.12% salidroside) or its active principles were given by gavage 1h before access to HPF. Only rats exposed to both food restrictions and stress exhibited BE in the first 15-60min after the stressful procedure. R. rosea extract 10mg/kg significantly reduced and 20mg/kg abolished the BE episode. R. rosea extract 20mg/kg abolished also stress-induced increase in serum corticosterone levels. The R. rosea active principle salidroside, but not rosavin, at doses present in the extract, dose-dependently reduced or abolished BE for the period in which it was elicited. In conclusion results indicate that R. rosea extracts may have therapeutic properties in bingeing-related eating disorders and that salidroside is the active principle responsible for this effect.

Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating / Cifani, C; Micioni Di B., Mv; Vitale, Giovanni; Ruggieri, Valentina; Ciccocioppo, R; Massi, M.. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - STAMPA. - 101 (5):(2010), pp. 555-562. [10.1016/j.physbeh.2010.09.006]

Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating.

VITALE, Giovanni;RUGGIERI, Valentina;
2010

Abstract

Stress is a key determinant of binge eating (BE). Since Rhodiola rosea is known to modulate stress responses, its effect in a model of BE was investigated. BE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/re-feeding (for 4days 66% of the usual chow intake; for 4days food ad libitum) and acute stress on the test day (day 25). R. rosea dry extract (3% rosavin, 3.12% salidroside) or its active principles were given by gavage 1h before access to HPF. Only rats exposed to both food restrictions and stress exhibited BE in the first 15-60min after the stressful procedure. R. rosea extract 10mg/kg significantly reduced and 20mg/kg abolished the BE episode. R. rosea extract 20mg/kg abolished also stress-induced increase in serum corticosterone levels. The R. rosea active principle salidroside, but not rosavin, at doses present in the extract, dose-dependently reduced or abolished BE for the period in which it was elicited. In conclusion results indicate that R. rosea extracts may have therapeutic properties in bingeing-related eating disorders and that salidroside is the active principle responsible for this effect.
2010
101 (5)
555
562
Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating / Cifani, C; Micioni Di B., Mv; Vitale, Giovanni; Ruggieri, Valentina; Ciccocioppo, R; Massi, M.. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - STAMPA. - 101 (5):(2010), pp. 555-562. [10.1016/j.physbeh.2010.09.006]
Cifani, C; Micioni Di B., Mv; Vitale, Giovanni; Ruggieri, Valentina; Ciccocioppo, R; Massi, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/647397
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