Abstract: A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, and ROS are, in turn, responsible for the maintenance of the cancer phenotype. Persistent ROS stress may induce adaptive stress responses, enabling cancer cells to survive with high levels of ROS and maintain cellular viability. However, excessive ROS levels render cancer cells highly susceptible to quercetin, one of the main dietary flavonoids. Quercetin depletes intracellular glutathione and increases intracellular ROS to a level that can cause cell death.

Interfering with ROS metabolism in cancer cells: the potential role of quercetin / Gibellini, Lara; Pinti, Marcello; Nasi, Milena; DE BIASI, Sara; Roat, Erika; Bertoncelli, Linda; Cossarizza, Andrea. - In: CANCERS. - ISSN 2072-6694. - STAMPA. - 2:(2010), pp. 1288-1311. [10.3390/cancers2021288]

Interfering with ROS metabolism in cancer cells: the potential role of quercetin.

GIBELLINI, Lara;PINTI, Marcello;NASI, Milena;DE BIASI, SARA;ROAT, ERIKA;BERTONCELLI, Linda;COSSARIZZA, Andrea
2010

Abstract

Abstract: A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, and ROS are, in turn, responsible for the maintenance of the cancer phenotype. Persistent ROS stress may induce adaptive stress responses, enabling cancer cells to survive with high levels of ROS and maintain cellular viability. However, excessive ROS levels render cancer cells highly susceptible to quercetin, one of the main dietary flavonoids. Quercetin depletes intracellular glutathione and increases intracellular ROS to a level that can cause cell death.
2
1288
1311
Interfering with ROS metabolism in cancer cells: the potential role of quercetin / Gibellini, Lara; Pinti, Marcello; Nasi, Milena; DE BIASI, Sara; Roat, Erika; Bertoncelli, Linda; Cossarizza, Andrea. - In: CANCERS. - ISSN 2072-6694. - STAMPA. - 2:(2010), pp. 1288-1311. [10.3390/cancers2021288]
Gibellini, Lara; Pinti, Marcello; Nasi, Milena; DE BIASI, Sara; Roat, Erika; Bertoncelli, Linda; Cossarizza, Andrea
File in questo prodotto:
File Dimensione Formato  
cancers-02-01288.pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 402.23 kB
Formato Adobe PDF
402.23 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/647392
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 161
  • ???jsp.display-item.citation.isi??? ND
social impact