INTRODUCTION: The average age of patients undergoing liver transplantation (LT) is consistently increasing. The aim of this case-control study is to evaluate survival and outcome of patients ≥65 yr compared to younger patients undergoing LT. MATERIALS AND METHODS: From 10/00 to 4/08 we performed 330 primary LT, 31 (9.4\%) of these were in patients aged 65-70. Following a case-control approach, we compared these patients with 31 patients aged between 41 and 64 yr and matched according to sex, LT indication, viral status, cadaveric/living donor, LT timing, and Model for End-Stage Liver Disease (MELD) score. RESULTS: There were no statistically significant differences in demographic and surgical donor characteristics. The mean MELD score was under 18 in both groups. Post-LT complications occurred with a similar incidence in the two groups. one-, three-, and five-yr survival was 83.9\%, 80.6\%, and 80.6\%, respectively, for the elderly group, and 80.6\%, 73.8\%, and 73.8\%, respectively, for the young group (p = 0.61). DISCUSSION: Patients aged between 65 and 70 with low MELD score who undergo LT have the same short- and middle-term survival expectancy, morbidity, and outcome quality as younger patients with the same indication and same pre-LT pathology severity, whatever they might be. Thus, chronological age alone should not deter LT workup in patients >65 and <70.

Liver transplantation in patients aged 65 and over: a case-control study / R., Montalti; G., Rompianesi; DI BENEDETTO, Fabrizio; R., Ballarin; R. C., Gerring; S., Busani; L. D., Pietri; N. D., Ruvo; R. M., Iemmolo; G. P., Guerrini; N., Smerieri; Gerunda, Giorgio Enrico. - In: CLINICAL TRANSPLANTATION. - ISSN 0902-0063. - STAMPA. - 24:(2010), pp. E188-E193. [10.1111/j.1399-0012.2010.01230.x]

Liver transplantation in patients aged 65 and over: a case-control study.

DI BENEDETTO, Fabrizio;S. Busani;GERUNDA, Giorgio Enrico
2010

Abstract

INTRODUCTION: The average age of patients undergoing liver transplantation (LT) is consistently increasing. The aim of this case-control study is to evaluate survival and outcome of patients ≥65 yr compared to younger patients undergoing LT. MATERIALS AND METHODS: From 10/00 to 4/08 we performed 330 primary LT, 31 (9.4\%) of these were in patients aged 65-70. Following a case-control approach, we compared these patients with 31 patients aged between 41 and 64 yr and matched according to sex, LT indication, viral status, cadaveric/living donor, LT timing, and Model for End-Stage Liver Disease (MELD) score. RESULTS: There were no statistically significant differences in demographic and surgical donor characteristics. The mean MELD score was under 18 in both groups. Post-LT complications occurred with a similar incidence in the two groups. one-, three-, and five-yr survival was 83.9\%, 80.6\%, and 80.6\%, respectively, for the elderly group, and 80.6\%, 73.8\%, and 73.8\%, respectively, for the young group (p = 0.61). DISCUSSION: Patients aged between 65 and 70 with low MELD score who undergo LT have the same short- and middle-term survival expectancy, morbidity, and outcome quality as younger patients with the same indication and same pre-LT pathology severity, whatever they might be. Thus, chronological age alone should not deter LT workup in patients >65 and <70.
2010
24
E188
E193
Liver transplantation in patients aged 65 and over: a case-control study / R., Montalti; G., Rompianesi; DI BENEDETTO, Fabrizio; R., Ballarin; R. C., Gerring; S., Busani; L. D., Pietri; N. D., Ruvo; R. M., Iemmolo; G. P., Guerrini; N., Smerieri; Gerunda, Giorgio Enrico. - In: CLINICAL TRANSPLANTATION. - ISSN 0902-0063. - STAMPA. - 24:(2010), pp. E188-E193. [10.1111/j.1399-0012.2010.01230.x]
R., Montalti; G., Rompianesi; DI BENEDETTO, Fabrizio; R., Ballarin; R. C., Gerring; S., Busani; L. D., Pietri; N. D., Ruvo; R. M., Iemmolo; G. P., Guerrini; N., Smerieri; Gerunda, Giorgio Enrico
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/647227
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