Since their initial description, mesenchymal progenitors have exhibited two general functions: to directly generate tissue by differentiation and to support the survival and proliferation of other cells/tissues by secreting cytokines or growth factors. This dual-function paradigm was represented in the original description of mesenchymal progenitors, now designated as marrow stromal cells (MSC), by their capacity to give rise to bone cells and to support hematopoiesis in vitro.
Getting beneath the skin to understand MSC complexity / Dominici, Massimo; E. M., Horwitz. - In: CYTOTHERAPY. - ISSN 1465-3249. - STAMPA. - 12:4(2010), pp. 438-439. [10.3109/14653249.2010.499712]
Getting beneath the skin to understand MSC complexity
DOMINICI, Massimo;
2010
Abstract
Since their initial description, mesenchymal progenitors have exhibited two general functions: to directly generate tissue by differentiation and to support the survival and proliferation of other cells/tissues by secreting cytokines or growth factors. This dual-function paradigm was represented in the original description of mesenchymal progenitors, now designated as marrow stromal cells (MSC), by their capacity to give rise to bone cells and to support hematopoiesis in vitro.
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